放射性稀土混合粉尘对工作人员的毒理学效应

摘要

Objective To investigate the toxicological effects of long-term exposure to mixed dust containing radiothorium rare earth on workers.Methods Single cell gel electrophomsis was used to examine the DNA comet length of peripheral blood lymphocytes,and then to evaluate the DNA damage degree according to the comet length.The lymphocyte cell method was used to examine the micronucleus formation rate of peripheral blood lymphocyte.Lung function instrumental MiCROSPRO HI-198 was used to determine the lung ventilation function.Result For exposure group and control group.the average values of comet length were(40.2±4.14)μm and(39.5±2.54)μm,respectively,while the frequency of micronucleus formation were(2.71±2.04)‰ and(0.79±0.91)‰.The lung function barrier formation were 70.9%and 64.9%,which means the exposure group was higher than that of control.Conclusions Mine mixed dust containing radiothofium rare earth may have certain toxicology eriects on the professional workers.%目的 探讨长期接触含放射性钍稀土混合粉尘对作业人员的毒理学效应.方法 单细胞凝胶电泳技术检测外周血淋巴细胞DNA彗星长度,根据彗星长度评价DNA损伤;采用Giemsa染色法检测外周血淋巴细胞微核率.结果 接尘和对照组人员外周血淋巴细胞彗星迁移长度平均值分别为(40.2±4.14)μm和(39.5±2.54)μm,两组差异无统计学意义(t=0.70,P0.05).微核率结果分别为(2.71±2.04)‰和(0.79±0.91)‰,两组差异有统计学意义(χ2=110.9,P<0.01);肺通气功能障碍发生率两组分别为70.9%和64.9%,接尘组高于对照组,差异有统计学意义(χ2=8.71,P<0.05).结论 含放射性稀土混合粉尘对职业工作者可产生一定的毒理学效应.