基于体素的形态测量法分析高功能孤独性障碍患儿的脑组织密度

摘要

目的 分析学龄孤独性障碍患儿脑组织密度.方法 对17例智能正常的孤独性障碍患儿(病例组)以及15名年龄、性别、智商与之相匹配的健康儿童(对照组)进行T1加权三维磁共振成像扫描,应用基于体素的形态测量法(VBM)比较两组脑灰质及脑白质密度的差异.结果 与对照组相比,孤独性障碍患儿右侧小脑前叶的脑灰质密度低.右前扣带回、右额中回区域的脑白质密度低,双侧顶下小叶、右缘上回、右中央后回、右颞上回、右小脑后叶、左楔前叶、左楔叶的脑灰质密度高(P<0.001).结论 智力正常的学龄孤独性障碍患儿脑组织密度异常明显,且部位广泛.%Objective To assess the density difference in the cerebral grey and white matter in children with autistic disorder. Methods Voxel based morphometry (VBM) in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 17 autistic disorder children and 15 normal controls. Results Compared with the controls, the grey matter density in autistic disorder children had significant decrease in the fight anterior lobe of cerebellum and increase in the bilateral inferior parietal lobule, right supramarginsl gyrus, right postcentral gyrus, right posterior lobe of cerebellum, right superior temporal gyms, left precunens and left cuneus (P<0.001). Significant dusters of reduced white matter density were found in the region of right anterior cingulated and right medial frontal gyms (P< 0.001) in autistic disorder children in comparison with controls. Conclusion The findings indicate structural grey and whim matter are significantly abnormal in children with autistic disorder and the deficits are widespread in brain regions.