信仰指数和载脂蛋白E基因的交互作用与轻度认知功能障碍患病风险的相关分析

摘要

Objective To explore the interactions between belief index and apolipoprotein E (ApoE) gene polymorphism in association of the risk of cognitive function. Methods Two thousand four hundred and ten community dwellings aged 55 years and over were enrolled in health check program in Ningxia Hui Autonomous Region, and fasting venous blood was collected to detect ApoE gene polymorphisms using high resolution melting curve method. The MMSE coupled with Duke University Religion Index was administered to assess the cognitive function and belief index. Crossover analysis and logistic regression model was employed detecting the interaction effect. Results Four hundred and sixteen (17.3%,416/2410) participants met the criteria of mild cognitive impairment (MCI), and 58.0%(1399/2410) participants with high belief index.The proportion of ?4 carrier, ?2 carrier were 14.9% (358/2410) and 14.5% (350/2410), respectively. The crossover analysis showed the synergy index was 0.40, indicated an antagonism between belief index and?4 allele. Participants with?4 allele carrier with low belief index had the highest risk of MCI (OR=1.95, 95%CI 1.24-3.07) compared with those without?4 allele carrier with low religiosity. Logistic regression model revealed a persist antagonism between belief index and ?4 allele (β=-0.76, OR=0.47, 95%CI 0.25-0.86,P=0.015) under controlled covariables age, gender, hypertension and blood glucose abnormalities. Conclusion The negative interaction of belief index with ApoE?4 allele may be significantly associated with the reduced risk of MCI.%目的 分析信仰指数和载脂蛋白E(apolipoprotein E,ApoE)基因多态性的交互作用与轻度认知功能障碍(mild cognitive impairment,MCI)患病风险的相关关系.方法 纳入2410名宁夏回族自治区社区健康体检的55岁及以上居民,收集空腹静脉血,采用高通量溶解曲线法分型鉴定ApoE基因多态性,分别采用MMSE、杜克信仰指数量表测评认知功能和信仰指数;叉生分析和Logistic回归模型用于检验ApoE等位基因多态性与信仰指数的交互效应.结果 17.3%(416/2410)的研究对象符合MCI诊断标准,58.0%(1399/2410)的研究对象为高信仰指数者;携带?4等位基因者和携带?2等位基因者分别为14.9%(358/2410)和14.5%(350/2410);叉生分析显示信仰指数与ApoE?4等位基因之间存在拮抗作用,交互指数为0.40;与未携带ApoE?4等位基因且信仰指数低者相比,携带ApoE?4等位基因且信仰指数低者MCI患病风险较高(OR=1.95,95%CI 1.24~3.07).Logistic回归模型显示控制年龄、性别、高血压、空腹血糖异常等变量后,高信仰指数与携带ApoE?4等位基因具有显著的负交互作用(β=-0.76,OR=0.47,95%CI 0.25~0.86,P=0.015).结论 信仰指数和ApoE?4等位基因之间存在负交互作用,其可能会降低MCI的患病风险.