Objective:To investigate the bone regeneration surrounding Ti-24Nb-4Zr-8Sn modified and Bio-Oss im-plants by micro-arc oxidation and alkali-heat treatment (MAH).Methods:Cylinder-like specimens (3mm in diameter and 10mm in height) were made from Ti2448 alloy, and divided into two groups with different surface treatments: polished (Ti2448), and micro-arc oxidation and alkali-heat treatment (MAH-Ti2448). Bone defects were obtained by extracting mandible second, third, fourth premolars of three adult dogs. The cylinder implant specimens were placed into the extracted sockets, and then the Bio-Oss was placed into the bone defects. After 4 weeks, the bone structure were evaluated through histological microscopy.Results:After 4 weeks, bone defects surrounding MAH-Ti2448 and Bio-Oss were filled with os-teoid and newly formed bones in conjunction with the implants. Few osteoid was observed around Bio-Oss, and osseo-inte-gration was not formed in the implant-bone interface of the polished Ti 2448 specimens.Conclusions:MAH surface treat-ment and Bio-Oss could enhance the process of bone formation and improve the implant-bone integration.%目的：探讨经微弧氧化碱热处理(Micro-arc oxidation and alkali heatment，MAH)后Ti-24Nb-4Zr-8Sn合金和Bio-Oss修复种植体周围骨缺损的愈合情况。方法：Ti-24Nb-4Zr-8Sn合金制备成圆柱状样本，分二组(光滑表面和微弧氧化碱热组)进行表面处理。拔除犬下颌第二、三、四前磨牙，拔牙窝周围制备骨缺损，将两组种植体随机植入拔牙窝内，缺损区放置Bio-Oss，1个月后组织学染色观察种植体周围骨缺损的修复情况。结果：微弧氧化碱热种植体周围及Bio-Oss颗粒表面类骨质多而密，种植体表面可见大量新生骨的存在， BIC达25.68±5.2%。光滑表面种植体周围的骨缺损区， Bio-Oss颗粒周围新生骨较少，种植体表面未见新生骨的存在。结论： MAH和Bio-Oss可促进种植体周围骨缺损的修复及种植体骨整合。
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