缺铁性贫血患者脑血流动力学的变化

摘要

目的 应用经颅多普勒超声(TCD)分析缺铁性贫血(IDA)的脑血流动力学特点并探讨TCD的诊断价值.方法 对46例IDA患者(中重度贫血组28例,轻度贫血组18例)行TCD检测,观察其脑血流动力学改变,并与40例健康者(对照组)比较.结果 除3例TCD结果正常外,其余贫血患者脑血流广泛增高.中重度贫血组血流速度显著高于轻度贫血组(P<.05),两组均显著高于对照组(P<0.01).中重度贫血组搏动指数显著低于对照组(P<0.01).IDA患者中有2例TCD诊断血管狭窄,5例有晕厥发作.结论 脑血流速度的增高程度可初步反映贫血的严重程度,TCD检测IDA患者有助于评估其血流代偿能力,提高脑血管狭窄的发现率.%Objective To analyze the hemodynamic characteristics in patients with iron deficiency anemia(IDA) using transcranial Doppler ultrasonography(TCD),and to discuss the diagnostic value of it.Methods There were 46 patients with IDA,among them 28 patients had moderate or severe anemia,and 18 patients had mild anemia.Hemodynamic changes in patients were observed with TCD,and compared with 40 case healthy controls. Results In addition to 3 case results of TCD were normal,the increase of velocity were found in the others patients.The cerenbral blood flow velocity of the moderate or severe anemia group were significantly higher than that of the mild anemia group(P<0.05),and these were significantly higher than that of the control group(P<0.01).The pulsatility index of the moderate or severe anemia group were significantly lower than that of the control group(P<0.01).2 case artery stenosis in 46 patients were found by TCD,there were 5 case with syncope in 46 patients.Conclusion The severness of anemia can be observed by the increased cerenbral blood flow velocities.TCD may be evaluat Effestiveness of blood flow,and TCD may be possible to raise the discover rate of artery stenosis in anemia.