Objective To investigate the cognitive function and its relevant factors in schizophrenia. Methods We used WAIS to assess 80 patients with schizophrenia and 65 normal controls. We also investigated the clinical feature of pa-tients.Results IQ ,verbal IQ ,peiformance IQ of schizophrenia patients were significant lower than those of controls. The IQ of 75% patients are lower than that of the controls. The incidence of cognitive deficit in schizophrenia patients was 19%. The re-sult of multiple stepwise regression analysis shows :The age at onset was related to IQ. Patients with later age at onset showed higher IQ. Verbal IQ was related with the age at onset ,the types of diagnosis. Patients with later age at onset ,paranoid type showed higher verbal IQ.The course of desease was related to percomance IQ. Patients with shorter course of disease showed higher performance IQ.Conclusion The deficit of cognitive function in schizophrenia patients is obvious and extensive. It is in-fluenced by many factors.%目的：了解精神分裂症患者的认知功能及其影响因素。方法对80例精神分裂症患者及65例正常者对照进行韦氏智力测验（WAIS）评定，同时调查患者的临床特征。结果与正常对照比较发现，慢性精神分裂症患者的IQ、言语智商和操作智商均显著低于正常对照，75％患者的IQ低于正常，19％的患者智力缺损。多元逐步回归分析显示：（1）IQ与发病年龄有关，发病年龄越晚，I Q越高；（2）言语智商与发病年龄、诊断分型有关、发病年龄晚、偏执型患者，言语智商高；（3）操作智商与病程有关，病程越短，操作智商越高。结论慢性精神分裂症的认知功能损害是明显的、广泛的，受多种因素的影响的。
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