丙戊酸钠治疗偏头痛持续状态的有效性和安全性研究

摘要

Objective To investigate the effecacy and safety of sodium valproate in the treatment of status hemicranicus. Methods 84 cases of patients with status hemicranicus were randomly divided into observation group and control group ,42 ca‐ses in each group. The control group received dexamethasone intravenously ,the observation group received oral sodium val‐proate on the basis of the control group ,the clinical efficacy and adverse reactions of the two groups were compared.Results The effective rate of hemicranicus in observation group was 97.62% ,which was significantly higher than 83.33% in control group(P<0.05);after treatment ,the VAS scores in the observation group were significantly lower than the control group (P<0.05);there was no significant difference on adverse reactions between the two groups (P>0.05).Conclusion Status hemi‐cranicus adjuvant treatment for status hemicranicus has a significant effect ,but there may be bradycardia ,hypotension ,gastro‐intestinal discomfort and other adverse reactions ,need to strengthen the rational use of medicines management.%目的：探讨丙戊酸钠治疗偏头痛持续状态的有效性以及安全性。方法将84例偏头痛持续状态患者随机分为观察组与对照组，各42例。对照组予以地塞米松静滴，观察组在对照组的基础上予以丙戊酸钠口服，比较2组临床疗效与不良反应。结果观察组头痛缓解有效率97.62％，显著高于对照组的83.33％（P＜0.05）；治疗后观察组 VAS评分显著低于对照组（P＜0.05）；2组不良反应发生率无明显差异（P＞0.05）。结论丙戊酸钠辅助治疗偏头痛持续状态疗效显著，但可出现心动过缓、消化道不适及低血压等不良反应，需加强合理用药管理。