目的 观察凯西莱片对抗结核药物所致肝损害的防治效果. 方法 初治肺结核患者194例,予以2HRZS(E)/4HR方案抗结核化疗,治疗组98例,全程加服凯西莱片;对照组96例,全程加服葡醛内酯. 结果 治疗组出现肝损害7例(7.14%),其中HBsAg阳性患者出现肝损害3例(11.1%),老年患者2例(9.52%);对照组出现肝损害28例(29.17%),其中HBsAg阳性患者出现肝损害12例(48.0%),老年患者5例(23.8%). 结论 凯西莱片在预防抗结核药物所致肝损害中疗效显著,尤其是HBsAg阳性患者及老年肺结核患者.%Objective To determine the preventive efficacy of tiopronin tablets on medicamentous liver lesion by antitubercu-lesis drugs. Methods One hundred and ninety - four intially - treated pulmonary tuberculosis patients who received the regimen of 2HRZS(E)/4HR were randomly separated into two groups :observe group,98 cases ,supplemented with tiopronin tablets. Con-trol group, 96 cases, received glucarolactone. Results There were 7 cases who had liver damage in observe group(7.14%), 3 cases with HBsAg positive (11.1%), 2 cases were old people; there were 28 cases who had liver damage in control group (29.17%), 12 cases with HBSAg positive(48.0%),5 cases were old people. Conclusion Tiopronin tablets is effective in pre-venting cause by anti - tuberculosis drugs, HBsAg positive and old patient's liver function should be monitored in the early period of centi - tuberculosis treatment.
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