原发性高血压病患者脉压及血清同型半胱氨酸与颈动脉内中膜厚度的关系

摘要

目的 探讨原发性高血压病患者脉压(PP)、血清同型半胱氨酸(HCY)水平与颈动脉内中膜厚度(CIMT)的关系.方法 原发性高血压患者选择64例根据高血压病史及入院时血压分为单纯收缩期高血压组(A组,22例)、全期型高血压组(B组,22例)、单纯舒张期高血压组(C组,20例),另设健康对照组(N组,21例).分别检测脉压(PP),应用酶联免疫吸附法(ELISA)测定血清HCY水平,超声诊断仪测定颈动脉内中膜厚度.结果 ①原发性高血压病患者血清同型半胱氨酸水平(HCY)显著高于正常对照组(P＜0.01);单纯收缩期高血压组(A组)PP与血HCY高于其他类型的高血压组(P＜0.05).②原发性高血压病患者的颈动脉内中膜厚度(CIMT)显著高于正常对照组(P＜0.01);单纯收缩期高血压组(A组)CIMT高于其他类型的高血压组(P＜0.05).结论 PP及血HCY升高可能是造成原发性高血压患者动脉粥样硬化的重要因素.%Objective To investigate the relationship between pulse pressure and serum homocysteine level and carotid intimia-media thickness in essential hypertensive patients.Methods Sixty-four essential hypertensive patients were grouped as the simple systolic hypertensive group(group A,n=22),systolic and diastolic hypertensive group(group B,n=22),the simple diastolic hypertensive group(group C,n=20),21 healthy subjects served as control(group N,n=20).Pulse pressures were measured,serum level of homocysteine were determined using ELISA method.Carotid intimia-media thickness were measured or calculated by establish formulas.Results ①Serum homocyteine level in hypertensive group was significantly higher than normotensive group(P＜0.01),the pulse pressure and serum homocysteine level with A group were significantly higher than other groups(P＜0.01).②Carotid intimia-media thickness in hypertensive group were significantly higher than normotensive group(P＜0.01).The carotid intimia-media thickness in A group were higher than other groups(P＜0.05).Conclusion Pulse pressure and serum homocysteine level may be play important roles in arterial atherosclerosis in essential hypertension.