人表皮生长因子受体2在卵巢上皮性癌组织中的过表达及其预后价值

摘要

Objective To investigate the overexpression of HER-2eu(c-erbB-2) in epithelial ovarian cancer and the relationship between HER-2eu overexpression and its prognostic significance. Methods The overexpression of HER-2eu was detected by immunohistochemistry in 77 ovarian carcionma. Correlations between HER-2eu overexpression and clinicopathologic features and survival time of epithelial ovarian cancer were analyzed. Results The overexpression rate of HER-2eu in epithelial ovarian carcionma was 28.6%. In univariate analysis, significant difference in median survival time was observed between HER-2eu overexpression patients and HER-2eu expression negative patients(P＝0.001). In multivariate analysis, HER-2eu overexpression was an independent prognostic factor of epithelial ovarian cancer(P＝0.032).Conclusions HER-2eu overexpression plays an important role in the genesis and progression of epithelial ovarian carcionma. It is an independent prognostic factor of ovarian carcinoma.%目的 探讨卵巢上皮性癌组织中人表皮生长因子受体(HER)-2eu(c-erbB-2)的过表达及其与卵巢上皮性癌患者预后的关系.方法 采用免疫组化染色法检测77例卵巢上皮性癌组织中HER-2eu的过表达,分析其与卵巢上皮性癌临床病理因素和生存时间之间的相关性.结果 卵巢上皮性癌组织中HER-2eu的过表达率为28.6%.单因素分析显示,HER-2eu过表达阳性患者的中位生存时间(25.7个月)明显短于HER-2eu过表达阴性者(>34.1个月,P＝0.001).多因素分析显示, HER-2eu过表达是影响患者预后的独立因素(P＝0.032).结论 HER-2eu过表达在卵巢上皮性癌的发生和进展中起重要作用,是影响患者预后的独立危险因素.