增大剂量的氨氯地平对高血压病患者血压及微量白蛋白尿的影响

摘要

Objective To investigate the effect of increasing dose of amlodipine on blood pressure and microalbuminuria in patients with hypertension.Methods A prospective self- controlled clinical trail with 60 patients enrolled was performed in the 12 - week study of amlodipine.Dose of amlodipine was doubled every 4 weeks from the initial dose of 2.5 mg,q12 h for the inadequately controlled hypertension patients.Blood pressure and urinary protein excretion,side effects were recorded simultaneously.Results Blood pressure decreased remarkably after 4,8,12 weeks.Proteinuria decreased significantly after 4 weeks (P ＜ 0.01 ),there was no significant difference between 8th week,12th week and 4th week (P ＞ 0.05).Conclusions Amlodipine reduces blood pressure in a time - dose dependent manner.Small - dose amlodipine have protective effect on renal damage.%目的 观察增大剂量的氨氯地平对高血压病患者血压及微量白蛋白尿的影响.方法 采用前瞻性、自身对照试验,为期12周.60例原发性高血压病伴微量白蛋白尿患者,氨氯地平起始剂量为2.Smg,每12小时1次,血压未达标者[坐位舒张压＞90 mm Hg(1 mm Hg=0.133 kPa)]每4周在原有基础上剂量增加1倍.治疗过程中监测血压及尿微量白蛋白及不良反应发生情况.结果 试验4、8、12周时血压均明显下降(P＜0.01).尿微量白蛋白4周时明显下降(P＜0.01),8周、12周与4周比较差异无统计学意义(P＞0.05).结论 氨氯地平的降压作用呈时间-剂量依赖性,小剂量氨氯地平已可发挥肾保护作用.