儿童孤独症全血微量元素及血铅水平分析

摘要

目的 总结分析儿童孤独症与全血微量元素、血铅水平之间的关系.方法 选择2012年1月至2013年12月洛阳市妇女儿童医疗保健中心收治的50例孤独症儿童为研究组,另选取同期健康检查的50例健康儿童为对照组,所有儿童抽取全血标本,利用火焰原子吸收分光光度方法测定锌、铜、铁、钙、镁等微量元素,再利用石墨炉原子吸收光谱法检测血标本中铅含量,最后采用孤独症行为量表(ABC)评估研究组患儿症状.结果 研究组血铜[(0.82±0.12)μg/ml]明显高于对照组,血锌水平[(6.22±1.23) μg/ml]明显低于对照组,血铅水平[(84.69±15.67) μg/L]明显高于对照组,两组比较差异有统计学意义(P＜0.05);研究组血锌水平与ABC线性分析呈负相关关系,血铜、血铅水平与ABC评分线性分析呈正相关关系.结论 与正常健康儿童相比,孤独症儿童全血微量元素发生了显著变化,其中血锌降低、血铜升高、血铅升高,这些元素变化水平与孤独症儿童症状严重程度有密切关系.%Objective To investigate the correlation of trace elements,blood lead levels with childhood autism.Methods Fifty patients with childhood autism from January 2012 to December 2013 were selected as study group,and fifty cases of healthy children in the same period were selected as control group.The elements of copper,iron,zinc,magnesium,and calcium were determined in whole blood using atomic absorptions spectrophotometer.The blood specimens of lead was determined by graphite furnace atomic absorption spectrometry.Children with symptoms were analyzed by ABC (Autism Behavior Checklist).Results The blood copper of study group[(0.82 ±0.12)μg/ml] was significantly higher than that of the control group;blood zinc level [(6.22 ± 1.23) μg/ml] was significantly lower than that of the control group;blood lead level [(84.69 ± 15.67) μg/L] was significantly higher than that of the control group (P ＜ 0.05).The blood zinc level of study group was negatively related with ABC linear analysis;The blood copper,blood lead level of study group was positively correlated with ABC rating linear analysis.Conclusions Compared with the normal,healthy children,trace elements in whole blood of children with autism have significant changes,including reduced blood zinc and copper,higher blood lead,these elements change levels are closely correlated with the severity of children with autism symptoms.