成人中枢神经系统感染血清及脑脊液降钙素原检测的临床意义

摘要

目的 探讨成人中枢神经系统感染血清及脑脊液降钙素原(PCT)检测的临床意义.方法 对87例成人中枢神经系统感染患者入院当日留取静脉血及脑脊液标本,采用双抗夹心法测定标本PCT水平.结果 化脑组血清及脑脊液PCT水平均高于病脑组、结脑组及神经梅毒组(P＜0.01).结论 血清及脑脊液PCT测定有助于鉴别中枢神经系统细菌性感染与非细菌性感染.%Objective To detect the clinical value of the blood serum and cerebrospinal fluid (CSF) procalcitonin (PCT) for patients with central nervous system infection.Methods A total of the patients (n =87) with severe cerebral stroke were involved.Double antibody sandwich assay was used to detect blood serum and CSF procalcitonin in the first day after hospital admission.Results Blood serum and CSF PCT levels were significantly higher in the group of purulent meningitis than those in the group of viral,tuberculous meningitis and neurosphilis.Conclusions Blood serum and CSF PCT level are better indicator to discriminate bacterial infection from non-bacterial infection in central nervous system infection.