妊娠期糖尿病患者血清微量元素及维生素D水平的临床分析

摘要

Objective To investigate the relationship between serum trace elements,1,25-hy-droxy vitamin D[1,25(OH) 2 D3 ]and gestational diabetes mellitus. Methods Sixty-four gestational diabet-ics patients and 53 healthy pregnant women were chosen and divided into patient group(64 cases)and con-trol group (53 cases)respectively. Clinical parameters such as age,gestational weeks and body mass index (BMI)were recorded. The levels of serum trace elements(copper,zinc,calcium,magnesium,iron)and 1,25(OH) 2 D3 were measured and compared between the two groups. Results There were no significant difference in age,gestational weeks or BMI between the two groups(P >0. 05). The levels of serum zinc, iron and 1,25(OH) 2 D3 of the patient group were lower than those of the control group (P <0. 05). There was no significant difference in the level of serum copper,calcium or magnesium between two groups(P >0. 05). Binary Logistic regression analysis showed that serum zinc,iron and 1,25(OH) 2 D3 levels were in-dependent risk factors for GDM occurrence. Conclusions The levels of trace elements zinc,iron and 1,25(OH) 2 D3 may increase the progression of GDM and they should be intervened as early as possible.%目的 探讨血清微量元素及1,25羟-维生素D 3[(1,25(OH)2D3)]与妊娠期糖尿病(GDM)的关系.方法 选择64例GDM患者作为病例组,53例正常妊娠期妇女作为对照组,记录两组年龄、孕周、体质量指数(BMI),并测定血清铜、锌、钙、镁、铁及1,25(OH)2 D3水平,比较两组临床及实验室数据差异.结果 两组间年龄、孕周、BMI比较差异未见统计学意义(P>0.05);病例组血清锌、铁及1,25(OH)2 D3水平低于对照组(P<0.05);两组间铜、钙、镁水平比较差异未见统计学意义(P>0.05).二元Logistic回归分析显示锌、铁及1,25(OH)2 D3水平是GDM发生的独立危险因素(P<0.05).结论 体内微量元素锌、铁及维生素D水平可能与GDM的发生发展有关,应尽早干预.