健康男性血浆kisspeptin与迟发性性腺功能减退关系研究

摘要

目的 探讨健康男性血浆kisspeptin与更年期发生的关系.方法 对上海市宝山区99名健康志愿者进行PADAM问卷调查、外周血激素测定,分析血浆kisspeptin与年龄、更年期发生及激素间的关系.结果 成年男性99名血浆kisspeptin随年龄增加而增长,PADAM症状阳性率也随年龄增高.PADAM症状阳性组与阴性组间年龄差异有统计学意义(P＜0.01),而kisspeptin差异无统计学意义(P＞0.05).血浆kisspeptin与年龄(P＜0.01)、雌二醇( E2) (P =0.039)密切相关,年龄是血浆kisspeptin变化的重要影响因素(P=0.004).结论 血浆kisspeptin与更年期发生无明显关系,提示成年后kisspeptin在HPG轴中的作用可能不及青春期启动时重要.%Objective To investigate the relationship between plasma kisspeptin levels and male menopause. Methods 99 male adults were recruited. Serum LH,FSH,T,fT,PRL,E2 and SHBG were measured by chemiluminescence analysis,and plasma kisspeptin by ELISA. The data was statistically analyzed using SPSS17. 0. The relationship of plasma kisspeptin levels with male menopause was investigated according to PADAM questionnaire. Results Plasma kisspeptin levels and the number of subjects with PADAM were increased with age. There was significant difference by age between PADAM and non-PADAM group(P<0. 01), however, plasma kisspeptin levels were not significantly different in these two different groups (P > 0. 05). Plasma kisspeptin levels were correlated with age (P < 0. 01) and serum E2 (P = 0. 039), but not with BMI, LH,FSH,T,fT(P>0. 05). Age was also the only factor influencing plasma kisspeptin levels. Conclusion Plasma kisspeptin levels were not associated with the male menopause, which suggests that kisspeptin does not play a crucial role in regulation of HPG axis in adults.