Objective To investigate whether there is a correlation between anemia, other clinicopathologic variables, and survival in early cervical cancer patients treated surgically. Methods 454 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I B ~ H A cervical carcinoma and treated with surgery were retro-spectivly analysed. Anemia was defined in terms of hemoglobin concentration less than 1 lOg/L. The relationships among pre-treatment anemia presence, clinicopathologic features and prognosis of these patients were evaluated. Results The prevalence of anemia in our patients was 21. 8% ( n = 99). Anemia presence was significantly associated with FIGO stage flA(P= 0.001), tumor diameter >4cm (P< 0.001), lymph vascular space invasion (LVSI, P = 0.028) , positive parametrium invasion (P= 0.030) and pelvic lymph node metastasis (P < 0.001). The multivariate analysis revealed that anemia was one of the independent risk factors for predicting pelvic lymph-node metastasis. The 5-year overall survival (OS) for anemic and non-anemic patients were 72% and 88% respectively(/'< 0.001). Using the Cox regression analysis, anemia(P= 0.027) ^LVSI(P= 0.002)and pelvic lymph nodes metastasis(P < 0.001 )were significant and independent prognostic factors of OS in early cervical cancer patients treated with surgery. Conclusion Pre-treatment anemia is associated with pelvic lymph node metastasis and poor overall survival in patients with early stage cervical cancer.%目的 探讨早期子宫颈癌患者贫血与临床病理因素之间的关系,并分析其对患者生存率的影响.方法 回顾性分析454例FIGO分期IB-IIA期的子宫颈癌患者临床病理资料,根据术前血红蛋白质量浓度,将患者分为贫血组(HB<110g/L)和非贫血组(HB≥110g/L),比较两组患者临床病理指标之间的差异,并作相关生存分析.结果 99例(21.8%)子宫颈癌患者术前伴有贫血.贫血与FIGO分期晚(P=0.001),肿瘤大于4cm(P<0.001)、琳巴血管间隙侵犯(LVSI,P= 0.028)、宫旁浸润(P = 0.030)以及盆腔淋巴结转移(P<0.001)均显著相关,并且是预测盆腔淋巴结转移的独立危险因素之一.贫血组和非贫血组患者的5年总生存率分别为72%和88%(P<0.001).Cox比例风险回归模型分析显示贫血(P=0.027)、LVSI(P= 0.002)和盆腔淋巴结转移(P<0.001)是早期子宫颈癌的独立预后因素.结论 贫血与IB-IIA期子宫颈癌患者盆腔淋巴结转移相关,且预示患者预后不佳.
展开▼
