糖抗原199在卵巢成熟畸胎瘤诊断中的临床意义

摘要

目的 探讨糖抗原199(CA199)在卵巢成熟畸胎瘤诊断中的临床意义.方法 选取2004年1月至2008年10月在北京协和医院妇产科进行手术并且术前进行包括CA199在内的4种肿瘤标志物检查的卵巢畸胎瘤患者263例进行分析.结果 在4种肿瘤标志物中,CA199的阳性率最高,为38.4%.4例有畸胎瘤剔除史患者的CA199水平均高于正常.畸胎瘤的最大径线平均大小为(7.07 ±3.22)cm.CA199、CA125升高组肿瘤大于正常组(P＜0.001).当肿瘤为多房表现时,血清CA199、CA125水平较单房者明显升高(P＜0.05);当肿瘤发生于双侧卵巢时,CA199显著升高(P＜0.05).结论 CA199在卵巢成熟畸胎瘤的诊断与鉴别诊断中具有一定的意义.当血清CA199水平升高时,无论对侧卵巢外观是否正常,手术时均应仔细检查对侧卵巢.CA199是否可作为临床检测卵巢畸胎瘤复发的指标有待于进一步的研究证实.%Objective To evaluate the clinical significance of CA199 in mature ovarian teratoma. Methods We retrospectively studied 263 patients operated at Peking Uinion Medical College Hospital between January 2004 and October 2008, whose tumor markers including CA199 was studied before the operation. Results Among the four tumor markers,CA199 showed the highest positive rate of 38. 4％. CA199 of 4 cases with history of teratoma were all elevated. The mean tumor diameter was (7.07 ±3. 22)cm. The mean tumor size of patients with elevated CA 199、CA125 was greater than those with normal CA199 、CA125 level (P ＜0. 001 ). Serum CA199, CA125 levels were significantly higher in those with multi-room teratoma than with single-room teratoma ( P ＜ 0. 05 ). Patients with bilateral teratomas showed a significantly higher rate of CA199 than those with unilateral ones( P ＜ 0. 05 ). Conclusion CA199 may have significance in the diagnosis of mature ovarian teratoma. Whether CA199 be used as a marker for detecting mature ovarian teratoma recurrence needs further clinical research.