围产期感染对子代近远期中枢神经系统的影响

摘要

The pathogenic microorganisms of perinatal infection include bacteria,viruses,protozoa,etc.It increases the risk of perinatal brain injury which is even more serious than hypoxia ischemic injury,when fatal immature brain is exposed to intrauterine infection/inflammation.The bad neurodevelopmental outcomes not only include cognitive disorders,epilepsy,cerebral palsy,but also increase the risk of children suffuring autism and schizophrenia.Here we have a overview of perinatal infection and emphase on the near-and longterm influence of perinatal infection on the children' s central nervous system.%围产期感染的病原微生物包括细菌、病毒、原虫等.胎儿未成熟的大脑暴露于宫内感染、炎症的环境中时,早产儿或足月儿脑损伤的风险增加,而且此损伤甚至比出生时罹患缺氧、缺血所导致的脑损伤更为严重,其不良神经发育结局不仅包括认知障碍、癫痫、脑瘫,甚至会增加子代自闭症、精神分裂症等风险.文章重点阐述围产期感染概况以及对子代近远期中枢神经系统的影响.