Objective To evaluate the clinical pathology meaning of atypical squamous cell of undetermined significance (ASCUS) in cervical cytology. Methods The clinical data of 2118 cases who underwent cervical liquid thin-prep cell test (TCT) were analyzed retrospectively, ASCUS and squamous epithelium (SIL) were diagnosed according to the classification of the data TBS cytology, the histopathological examination results were tracked. Results The incidence of ASCUS was 3.4% (72/2218), and the ratio for SIL ( 1.2%, 25/2118) was 2.9. In the cellular pathology of ASCUS, there were four aspects, atypical surface cells and atypical hollowed cells in 16 cases (22.2%), atypical atrophy of the squamous epithelial cells in 11 cases (15.3%), atypical mature or immature metaplastic cells 28 cases (38.9%), atypical cells less influence diagnosis 17 cases (23.6%). Tracking the histologic findings in 43 cases with chronic cervicitis 22 cases (51.2%), low level squamous epithelium neoplasia in 12 cases (27.9%), high levels of squamous epithelial change in 8 cases (18.6%), squamous cell carcinoma 1 case(2.3%). Conclusion ASCUS exists within the risk of squamous lesions, management should be strengthened.%目的 评价宫颈细胞学中诊断为未明确诊断意义的不典型鳞状细胞(ASCUS)的临床病理学意义.方法 回顾性分析2118例行宫颈液基薄层细胞学检查(TCT)患者的临床资料,按照TBS细胞学分类法诊断ASCUS和鳞状上皮内病变(SIL)的发生情况,并追踪组织病理学结果.结果 2118例中诊断为ASCUS 72例,检出率为3.4%,是SIL(1.2%,25/2118)的2.9倍.72例ASCUS的细胞病理学表现:不典型中表层鳞状细胞和不典型挖空细胞16例(22.2%)、不典型萎缩的鳞状细胞11例(15.3%)、不典型成熟或不成熟化生细胞28例(38.9%)、其他不典型细胞17例(23.6%).其中43例有组织病理学结果:慢性宫颈炎22例(51.2%)、低级别鳞状上皮内瘤变12例(27.9%)、高级别鳞状上皮内瘤变8例(18.6%)、鳞状细胞癌1例(2.3%).结论 ASCUS存在鳞状上皮内病变的危险,应加强管理.
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