阿苯达唑不良反应的文献分析

摘要

Objective To understand the adverse reactions of albendazole especially common serious adverse reactions and to provide information for the clinical and general public safe use of albendazole. Methods The articles of case report were searched out from the Chinese National Knowledge Infrastructure and National Center for Biotechnology. Then the case materials and articles were organized, summarized and analyzed. Results The adverse reactions of albendazole generally involve the digestive system, skin and appendages, nervous system and blood system. Serious ADRs of albendazole are encephalitis/demyelinating, hepatic injury, anaemia and leucopenia. Conclusion Albendazole is surely effective for the treatment of parasitic diseases, but the occurrence of adverse reactions should be valued to promote the safety and reasonable use of drug.%目的 了解阿苯达唑的不良反应尤其是常见严重不良反应,为指导临床和广大公众安全用药提供参考.方法 分别检索中国期刊全文数据库、美国国立生物技术信息中心数据库中阿苯达唑不良反应文献资料,并进行整理、归纳、统计和分析.结果 阿苯达唑不良反应主要累及消化系统、皮肤及其附件害、神经系统、血液系统等.常见严重不良反应主要包括:脑炎/脱髓鞘脑病、肝脏损害、贫血、白细胞减少.结论 阿苯达唑治疗寄生虫病临床疗效肯定,但应重视其不良反应的发生,促进安全合理用药.