53例药源性间质性肺炎的文献分析

摘要

目的：探讨引起间质性肺炎的药品种类及其临床表现特点。方法检索中国医院数字图书馆、中国知网、万方数据库中1994～2013年，关键词为“间质性肺炎”的相关文献，进行归纳总结。结果共检索出相关文献74篇，报道53例药源性间质性肺炎，涉及15种药物，包括吉非替尼（15例）、利妥西单抗（9例）、来氟米特（8例）、胺碘酮（8例）、厄洛替尼（5例）、干扰素（2例）、5-氟尿嘧啶（1例）、粒细胞集落刺激因子（1例）、吉西他滨（1例）、卡莫司汀（1例）、麻疹疫苗（1例）、百草枯（1例）等。53例患者中，2例治疗结果不详；治愈17例（33.33%），好转19例（37.26%），死亡15例（29.41%）。结论各药品引起间质性肺炎发病机制尚不明确，临床表现相似。发病率较高的药物有吉非替尼、利妥西单抗、来氟米特、胺碘酮、厄洛替尼。%Objective To study the drugs leading to interstitial pneumonia and analyze their clinical characteristics. Methods We searched the literatures from 1994 to 2013 by key words of "interstitial pneumonia" in China Digital Library, China National Knowledge Infrastructure, Wanfang Database, and summarized them. Results A total of 74 relevant articles were identified, which reported 53 cases of drug-induced interstitial neumonia, involving 15 kinds of drugs. The drugs included gefitinib(15), rituximab(9), leflunomide(8), amiodarone(8), erlotinib(5), interferon(2), 5-fluorouracil(1), granulocyte colony-stimulating factor(1), gemcitabine(1), carmustine (1), measles vaccine (1), paraquat(1), et al.The result showed that 53 cases contained 17 cases(33.33%) cured, 19 cases(37.26%) improved , 15 cases(29.41%) died and 2 cases unclear. Conclusion The clinical manifestations of interstitial pneumonia induced by drugs were similar, but the pathogenesis was unknown. The drugs leading to higher incidence were gefitinib, rituximab, leflunomide, amiodarone and erlotinib.