儿童臀肌挛缩症的诊治及病因学研究

摘要

本文报告该院治疗80例儿童臀肌挛缩症的临床资料、流行病学调查及儿童常用肌注药物的实验结果.认为我国儿童臀肌挛缩症的主要致病因素是婴儿期反复在臀肌注射苯甲醇青霉素.本病非手术治疗无效,臀肌松解术效果满意,应尽早手术.作者建议停止使用苯甲醇作为青霉素溶媒;并提出本病的诊断标准.%Eighty patients with bilateral contracted gluteal muscles,aged 4-9 years,were treated in 1983-1988.Among them,78 cases had a history of repeated intragluteal injections of penicillin.Releasing of contracted gluteal muscles and iliotibial band was performed on 135 hips in 68 patients.The follow-up survey showed satisfactory improvement of gluteal muscle function in all operated cases,while no improvement in the other 12 cases under conservative treatment.Among 317 children with a history of 2% benzy alcohol dissolved penicillin injections,21 suffered from the contracted gluteus.However,no one developed contracture in 316 children.using distilled water dissolved penicillin.An experiment with 44 rabbits showed that intragluteal injection of penicillin with 2% benzyalcohol solution resulted in myofibrosis.It is apparently that intragluteal injection of penicillin with benzylalcohol has been the main contributing factor in this group of patients.