Objective: To evaluate the efficacy of antidepressant in the treatment of postherpetic neuralgia (PHN). Metheds: 90 PHN patients were randomized into control group (n = 47) (conventional therapies such as anticonvulsants, opioids, nerve blockade, superlaser and so on) and paroxetine-treatment group (n = 43) (conventional therapies plus paroxetine 20 mg, qd). Pain intensity was evaluated with visual analogue scale (VAS) before and 30 days after treatment. Results: Compared with before treatment, the intensity of PHN patients decreased after treatment in both group (P < 0.05). The remission rate of pain intensity in paroxetine-treated group was higher than that in control group (P < 0.05). No serious paroxetine-related adverse effects were found. Conclusion: Antidepressant can improve the efficacy of conventional therapies in the treatment of PHN.%目的:评估抗抑郁药治疗带状疱疹后神经痛的疗效.方法:90例带状疱疹后神经痛患者随机分为对照组(n=47)和试验组(n=43).对照组采用常规疗法包括:药物治疗、物理治疗和微创治疗等.试验组在对照组的基础上加用抗抑郁药帕罗西汀20 mg,每天一次.采用视觉模拟评分法(visual analogue scale,VAS)分别于治疗前和治疗第30天评估疼痛强度,并计算疼痛缓解率.结果:两组治疗后比治疗前疼痛强度均显著降低(P＜0.05),治疗后组间比较,试验组疼痛缓解率显著高于对照组(P＜0.05).结论:抗抑郁药帕罗西汀可有效提高带状疱疹后神经痛的疗效.
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