偏头痛与心境障碍关系的Meta分析

摘要

目的:采用Meta分析对国内外已发表的有关偏头痛与心境障碍的相关文献进行综合分析,以探讨两者之间的相关性.方法:通过PubMed、The NEW ENGLAND JOURNAL of MEDICINE、中国期刊全文数据库(CJFD)和万方全文数据库进行检索,收集1988年1月～2011年12月发表的偏头痛与心境障碍关系的相关文献,应用Revman 5.0软件对所得资料进行Meta分析,选用固定效应模型进行合并效应量.结果:共纳入13项研究,偏头痛患者总数为9668例,其中偏头痛与抑郁共病的患者为2464例(25.5％)；偏头痛患者抑郁的发生率较非偏头痛患者高,差异有统计学意义(OR=3.18,95％ CI=2.96-3.43,P＜0.00001).结论:偏头痛患者患抑郁的风险是非偏头痛患者的3.18倍,偏头痛合并心境障碍的机制尚有待于研究.%Objective:To explore the association of migraine and mood disorders with meta analysis.Methods:PubMed,The New England Journal of Medicine,CJFD and WANFANG DATA were searched for relevant articles on the comorbidity of migraine and mood disorders published in between January 1988 and December 2011.Revman 5.0 softwares and the fixed effect model were used for meta-analysis.Results:Thirteen studies were finally included in this meta-analysis.The number of patients with migraine was 9668,of whom 2464(25.5％) patients were found comorbidity of depression.The results showed that the incidence of depression in migraineurs was significantly higher than in nonmigraineurs (OR =3.18,95％ CI =2.96-3.43,P ＜ 0.00001).Conclusion:The overall risk estimate gave an odd of depression for patients with migraine with respect to nonmigraineurs of more than three,the mechanism of comorbidity of migraine and mood disorders remains to be studied.