冰黄液外用治疗急性弥漫性外耳道炎的临床研究

摘要

Objective To evaluate the clinical curative effect of Binghuangye Ear Drops on Acute Diffuse External Otitis and whether it has acute toxicity by systematic clinical observation and experiment. Methods 92 cases of patients were divided randomly into the treatment group and the control group, the former was treated with Binghuangye Ear Drops and the latter with Ofloxacin Ear Drops.A comparative study on clinical curative effect between the control group and the treatment group was conducted by examing the main symptoms before and after the treatment in each group. To measure the Binghuangye ear drops'MlC with test tube methods, tested microbial species were Staphylococcus aureus, P. vulgaris, Streptococcus,P. aeruginosa. Results Binghuangye Ear Drops improved ear's pain and tickle;the action of alleviating ear's pain was relatively quick; the curative effect was obviously superior to the control group. The in-vitro bacteriostasis test enunciation,Binghuangye Ear Drops has bacteriostasis of Staphylococcus aureus, P. vulgaris, Streptococcus,P. aeruginosa in varying degrees. Conclusions Binghuangye Ear Drops can effectively improve the clinical symptoms of Acute Diffuse External Otitis,ameliorate quality of life, and its clinical use is safe.%目的 研究中药制剂冰黄液治疗急性弥漫性外耳道炎的临床疗效和作用机理以及用药的安全性.方法 将92例临床确诊的急性弥漫性外耳道炎患者随机分为冰黄液组(治疗组)及氧氟沙星组(对照组),以每组患者治疗前后主要症状、体征作为观察指征,进行临床疗效观察和对比.采用试管法对急性弥漫性外耳道炎常见致病菌进行体外抑菌试验.结果 冰黄液能明显改善急性弥漫性外耳道炎耳痛、耳痒等症状,缓解疼痛作用较为迅速,疗效优于对照组,且无明显毒副作用.对急性弥漫性外耳道炎常见致病菌均有不同程度的抑制作用.结论 冰黄液能有效改善急性弥漫性外耳道炎患者临床症状和体征,临床用药安全,是一种值得研究开发的外用新剂型中成药.