小型猪动物模型在耳科学领域的应用

摘要

小型猪与人的基因同源性高，各脏器及组织的大小结构和生理学等方面也极其相似，同时具有经济学和伦理学等方面的优势，作为耳科动物模型具有很好的应用前景。本文主要介绍小型猪在耳部解剖、内耳形态及电生理等方面与人的相似性，展示小型猪作为耳科学领域实验动物模型的优势。同时，归纳了目前小型猪动物模型在耳科领域，包括聋病的机制和治疗的相关基础研究、听觉植入相关研究、耳外科解剖教学等方面的应用现状。小型猪作为耳科领域的新兴动物模型将为耳科学及听力学的相关研究，为人类聋病的防治提供最理想的实验模型及论证。%The miniature pig genome is highly homologous to that of humans. The reasons for the use of the swine in otological research are its similarities in anatomy and physiology to humans, in addition to the financial and ethical advan-tages. In this review, we describe the anatomical, morphological, and electrophysiological characteristics of the miniature pig ear. We summarize the uses of the miniature pig in otological research, including deafness research, hearing implant and ear surgery training. The miniature pig is more suitable as an animal model for studying human hearing disorders and has the potential to become a cornerstone in otological and hearing research.