血脂、体重指数对老年男性腰椎骨密度降低并发颈动脉斑块形成的影响

摘要

Objective The purpose of this study was to learn the risk factors of the concurrence of osteoporosis and carotid artery plaque formation, through exploring the influence of blood lipid and BMI in decrease of bone mineral density and in formation of carotid artery plaque.Methods Han nationality male patients aged 60-80 years old were selected.The patients with diabetes, hyperparathyroid, chronic liver and kidney dysfunction, and those administered with drugs associated with bone metabolism or artery plaque formation in last 6 months, were excluded.Subjects were divided into normal control group ( group A ),carotid artery plaque formation group (group B), BMD decrease group (group C), and BMD decrease with carotid plaque formation group (group D ), according to results of BMD and carotid artery color Doppler ultrasound examination.The blood lipid levels and BMI were measured and compared among the four groups.Results ① BMI among the four groups were compared.The differences between group A and C,and between group A and D, were statistically significant.Patients with declined BMD showed lower BMI.BMI, to some extents, might be a protective factor of BMD.② Mean values of TC among the four groups were: Group D ＞ B ＞ A ＞ C.The differences between group A and D, between group C and D, were statistically significant.The difference between group A and D might be caused by the formation of carotid artery plaque.③ TG showed no statistical difference among the groups.④ HDL and LDL were no significant difference among the groups.Conclusion We could not confirm that BMI and lipid levels were risk factors of concurrence of decreased BMD and arterial plaque formation.%目的 通过探讨血脂、体重指数(BMI)在骨密度下降并发颈动脉粥样斑块形成的作用,以进一步了解两病共同发病的危险因素.方法 选取年龄60～80岁老年汉族男性患者,排除糖尿病、甲状旁腺功能亢进,排除慢性肝肾功能不全等疾病,排除6个月内服用影响骨代谢及动脉硬化形成药物,根据腰椎骨密度情况及颈动脉彩超情况,将研究对象分为,正常对照组(A组),单纯颈动脉斑块形成组(B组),单纯骨密度下降组(C组),骨密度下降合并颈动脉斑块形成组(D组).测定血脂、BMl水平,并在4组间进行比较.结果 ①BMl在4组间比较,仅在A～C组、A～D组之间有统计学意义.表明有骨密度下降的患者显示出较低的BMI,BMI在一定程度上可能为骨密度的保护因素.②TC在四组间的均值比较为:D组>B组>A组>C组,但仅在A～D,C～D之间的差异有意义,对照组(A组)与合并发病组(D组)之间的差异应该是由颈动脉斑块形成的因素的影响.③TG在4组间两两比较显示组间均无统计学差异.④HDL、LDL在4组间无统计学差异.结论 目前尚不能认为IMT、血脂水平是骨密度下降和动脉粥样斑块形成合并发病的危险因素.