Osteopontin (OPN) , a cytokine and chemotactic factor extensively expressed in the body , is able to mediate cell adhesion, aggregation, and migration. Meanwhile, it has dual function of both anti ?inflammatory and proinflammatory. Recently, people gradually realize the inestimable role of OPN played in cardiovascular diseases. OPN may have a function on stimulating cell proliferation and calcification of osteoblasts, promoting the adhesion between osteoclasts and bone matrix , improving the osteolytic activity, stimulating bone absorption and bone reconstruction , increasing the number and area of bone absorptive lacunae, and inhibiting the mineralization of bone tissue. This article reviews the function of OPN on the genesis of osteoporosis and arteriosclerosis%骨桥蛋白作为体内广泛存在的细胞因子和趋化因子,可介导细胞黏附,聚集及迁移,具有抗炎和促炎的双重作用,近年来逐渐认识到它在心血管疾病中起着不可估量的作用.骨桥蛋白可能刺激成骨细胞增殖、钙化,促进破骨细胞与骨基质的黏附并提高破骨细胞的溶骨活性,刺激骨吸收及骨重建,增加骨吸收陷窝的数量和面积,并抑制骨组织的矿化过程.本文就骨桥蛋白在骨质疏松症与动脉硬化的发病中所起作用作一综述.
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