Noggin是对机体多个系统的生长发育和重塑起重要调节作用的一种糖蛋白.其对神经系统和脑发育的影响已经为人们所熟知,近年来随着研究的不断深入,noggin对骨骼系统生长发育的显著作用逐渐被人们所认识:包括调节胚胎的形态发生,抑制体外成骨细胞增值与分化,抑制体内骨形成,调节颅缝融合和关节的正常形成以及辅助治疗骨肿瘤疾病等,是调节骨生长发育的重要细胞因子.其作用机制主要是通过与BMPs相互影响,调节BMPs信号通路的过程,间接调节骨形成.%Noggin is an essential glyooprotein in the growth, developinenl, and remodeling of many sysleins of human hody. Its influence on the nervous sjslein and brain development has been nell knoivn. While in recent jears, the significant role of .Noggin on the skeletal sjslem is in,:r-easingly being recognized, inc Juding regulation ofembryo morphogenesis, inhibition of the proliferation and differentiation of osleoblasls in vitro and bone formation in liui, adjustment of the fusion of suliira cranii and the formation of the joint, and the adjutant therapy of bone tumors. -Noggin is a vilal cjloLine in the regulation of the bone formation. The possible mechanism is that -Noggin interacts with BilP's, regulates Bill's signaling palhways, and regulates
展开▼
