肾性骨病动物模型的研究进展

摘要

Chronic kidney disease ( CKD) becomes one of the most vital diseases threatening human health.CKD is clinically characterized by increased morbidity and limited preventive measures. Renal osteodystrophy ( ROD ) is one of the major complications of CKD.An appropriate animal model for ROD appears to be very important for studying the pathological mechanisms and preventive drugs for ROD, even for CKD.This paper reviews the research progress on animal models for ROD induced by surgery, chemicals, or irradiation.The comparison and evaluation of the animal models provides theoretical evidence for the selection of ROD animal models in the pre-clinical basic study.%慢性肾脏病（ CKD）发病率高，防治率低，成为又一个威胁人类健康的重要疾病。肾性骨营养不良（ ROD）是CKD主要并发症之一。合适的ROD动物模型对研究ROD乃至CKD的病理机制及药物防治尤为重要。本文综述了由手术法、化学法、辐射法等致ROD的动物模型研究进展，并通过对各种动物模型的比较与评价，为今后临床前基础研究中ROD动物模型的选择提供一些理论依据。