氧化应激与糖尿病骨质疏松症相关性研究进展

摘要

Diabetic osteoporosis ( DOP ) is a systematic and metabolic skeleton disease accompanied with diabetes, which is characterized by the decrease of bone strength and bone mass, the increase of the bone fragility and fracture risk, and the change of bone microstructure. DOP seriously affects the health and quality of life of the patients. In recent years, a series of research concerning bone metabolism disturbance, bone mass loss, and fracture has made progress. However, the pathological mechanism remains uncertain. At present, some studies indicate that DOP is not only related to gender, age, disease course of diabetes, nutritional condition, race, and genetic factors, but also related to oxidative stress ( OS ) . This paper reviews the relationship between OS and DOP and the possible mechanism to provide the theory evidence for prevention and treatment of DOP.%糖尿病性骨质疏松是糖尿病并发单位体积内骨量减少、骨组织微结构改变、骨强度降低、脆性增加等易发生骨折的一种全身性、代谢性骨病，严重影响患者的健康和生活质量。近年，有关糖尿病骨矿代谢紊乱、骨量丢失、并发骨折等一系列问题的研究虽取得一定进展，但其发病机制仍未完全阐明。现有研究显示，糖尿病性骨质疏松除了与性别、年龄、糖尿病病程、营养状况、种族及遗传等因素有关之外，与氧化应激亦密切相关。本文就氧化应激与糖尿病性骨质疏松症的关系及其机制加以综述，为其预防和治疗提供理论依据。