两种干预周期脉冲电磁场对原发性骨质疏松症的疗效比较

摘要

Objective To compare the efficacy of different treatment periods with pulse electromagnetic fields ( PEMFs ) on primary osteoporosis. Methods A total of 124 cases of osteoporosis in our hospital from October 2010 to January 2012 were enrolled in this study. They were divided into whole period group and half period group. The patients in whole period group ( 62 cases) received 60 times PEMFs treatment, with 6⁃12Hz frequency and 9⁃11mT intensity, using a TY⁃PEMF A2 ( Tong⁃Ye Company, Tianjin) . Each treatment lasted for 40 minutes. The total course was 5 months. The patients in the half period treatment group received 30 times treatment. The total course was two and half months. All patients received calcium carbonate and vitamin D 300mg twice a day, alfacalcidol 1 ug once a day, and alendronate sodium pill 70 mg once a week. The bone mineral density of the total hip, femoral neck, and lumbar vertebral ( L2⁃L4 ) was detected before and after the treatment. Results The BMD of the total hip, femoral neck, and lumbar vertebral L2⁃L4 in both groups markedly increased after the treatment comparing to that before the treatment. The increasing rates of BMD in whole period group and half period group were 8�31 ± 1�01 and 5�45 ± 1�17 in the total hip, 8�58 ± 1�40 and 5�44 ± 1�52 in the femoral neck, and 8�02 ± 0�63 and 4�97 ± 0�49 in the lumbar vertebrae, respectively. The difference among them was statistically significant. Conclusion PEMFs combined with anti⁃osteoporosis drugs can increase the BMD of osteoporosis patients. The whole period of PEMFs has better efficacy than half period treatment.%目的：比较脉冲电磁场（ pulsed electric⁃magnetic fields， PEMFs）在原发性骨质疏松症骨重建周期全程干预和半程干预的疗效。方法收集我院2010年10月至2012年1月收治的原发性骨质疏松症患者124例，分成全程组和半程组。全程组62例，采用天津同业TY⁃PEMFA2型脉冲电磁场治疗仪，采用频率：6－12Hz，强度：9－11mT，共治疗60次，每次40 min，历时5个月。半程组62例，治疗30次，每次40 min，整个疗程历时2个半月。联合口服碳酸钙维生素D3片300 mg 2／d、阿法骨化醇软胶囊1 ug 1／d和阿仑磷酸钠片70 mg 1／w。治疗前后测定全髋、股骨颈和腰椎（ L2⁃L4） BMD值。结果与治疗前相比较，全程组和半程组全髋、股骨颈和腰椎（ L2⁃L4）骨密度均显著升高，两组BMD增长率（％）比较：total hip区全程组BMD为8�31±1�01，半程组5�45±1�17；股骨颈区全程组8�58±1�40，半程组5�44±1�52；腰椎全程组8�02±0�63，半程组4�97±0�49，各部位组间差异均有统计学意义。结论 PEMFs联合药物治疗原发性骨质疏松症，能明显提高患者的骨密度，全程组疗效优于半程组。