褪黑素与骨质疏松

摘要

褪黑素是由哺乳动物松果体分泌的一种吲哚类激素，通过促进成骨细胞增殖分化、抑制破骨细胞活性、诱导骨髓间充质干细胞向成骨细胞分化及抗氧化应激等多种方式增加骨量，可能为治疗骨质疏松提供新的策略和方法。%Melatonin is an endogenous hormone rhythmically produced in the pineal gland , researches demon-strate that melatonin may affect bone metabolism through bone anabolic , antiresorptive effects , osteogenesis of mesenchy-mal stem cells and anti-oxidative stress , so melatonin is a potential pharmacological agent for osteoporosis .