Synthesis of 1,7-Bis(4-hydroxyphenyl)hepta-4E,6E-dien-3-one

摘要

@@ Diarylheptanoids, most of which appearing in the areas of anti-inflammatory, anti-oxidative, super-oxide scavenging and anti-hepatotoxic effects, constitute a distinct group of metabolites of natural plants characterized by two aromatic rings linked by a linear seven aliphatic chain. We have investigated this kind of compounds and made some progress.[1]1,7-Bis(4-hydroxy-phenyl)hepta-4E,6E-dien-3-one (1) was firstly isolated from the seeds of Alpinia blepharocalyx.[2] So far the synthesis of the compound has not been reported yet. Herein, we report the synthesis of compound 1. The synthetic route is outlined in Scheme 1.