利用自适应光学技术对个性化像差矫正的初步探索

摘要

Objective To analyze the effects of different wavefront-guided aberration ablation patterns on visual function using adaptive optics technique and explore the effective and feasible pattern of customized refractive surgery.Methods Control study.Under dark condition, six volunteers'right eyes were fully dilated with 5 g/L phenylephedrine.The myopia and astigmatism were first fully corrected with optical lens, and then 100% contrast visual acuity of different wavefront correction patterns was detected using adaptive optics system in through a 6.0 mm pupil optical path.Results All of the eight different aberration correction strategies obtained excellent correciton effect.On the basis of this correction, visual acuity test was performed.The results showed that all aberration correction strategies improved the visual acuity compared with static correction.Correction of high order aberrations and full correction of aberrations could obtain better visual acuity than that of only correction of low order aberrations.Correction of aberrations from second to third order and fouth order spherical aberration second only to full correction of aberration.Conclusion As for low myopia patients, eliminating ocular high order aberrations could improve visual acuity.Correction of aberration from second to third order and fouth spherical aberration might be an effective and feasible pattern of customized refractive surgery.%目的 利用自适应光学技术分析不同的波前像差切削模式对视功能的影响,探索有效可行的个性化屈光手术模式.方法 对照研究.在暗环境下,对6位志愿者的右眼予以5 g/L盐酸去氧肾上腺素充分散瞳后,在6.0 mm瞳孔光路下,先通过光学镜片对其近视和散光进行充分预矫正,然后利用自适应光学系统进行不同波前像差矫正模式下100%对比度视力的检测.结果 8种不同的像差矫正策略均取得了极好的像差矫正效果.在此基础上进行视力测试,结果表明各种矫正策略均较静态矫正获得了视力的提高,矫正高阶像差和全矫像差比仅矫正低阶像差可获得更好的视力.矫正2～3阶像差和4阶球差获得了仅次于全矫像差的效果.结论 对于低度近视患者而言,消除眼高阶像差可以提高视力,矫正2～3阶像差和4阶球差可作为一种可行有效的个性化屈光手术模式.