面对葡萄膜黑色素瘤我们还能做些什么

摘要

葡萄膜黑色素瘤(UM)是成年人最常见的原发性眼内恶性肿瘤.目前已有的多种治疗方法尚未有效地改善患者的生命预后和提高生存率.基于上述问题,我们需要思考的是:对于UM我们还能做些什么?本文着重对于该肿瘤综合治疗中的局部保存治疗、预测评估肿瘤转移风险、早期发现肿瘤转移的检测以及是否需要对患者进行全身辅助治疗等问题进行评述.期望通过对肿瘤的病因学研究以及对各种治疗方法联合应用的治疗效果进行大样本前瞻性长期对照研究,能够寻找到既可保存患者眼球和有用视力,又能最大限度地改善患者生命预后的治疗方法;努力提高和推进我国UM的临床诊治水平.%Uveal melanoma (UM) is the most common intraocular malignant tumor in the adults. So far, known treatments have not been able to effectively improve the prognosis of the patients' life and the survival rate. Based on the above issues, it is imperative to think of what can we do for uveul melanoma. This paper reviews using local preservative therapy in combined treatment of UM, how to predict and evaluate the risk of metastasis, how to detect early metastasis, and whether or not systemic therapy to UM patients is necessary. We hope that through etiological study and through the evaluation of the effects of combined treatment of UM by large sample prospective control studies, we can find an effective therapy which can save the patients' eye and useful vision while simultaneously improving the prognosis, and ultimately, improving clinical diagnosis and treatment of UM in China.