高度近视眼全基因组关联研究的进展

摘要

As the results of both environmental and genetic factors,myopia is one of the most popular refractive errors in the world.In recent years,progressive achievements have been made in genome-wide association study (GWAS) of myopia and refractive error.A lot of susceptibility loci and regions have been found,which means the researches on genetic basis of myopia and refractive error entered a new stage.This review summarized the main advances,and indicated the possible directions of genetic studies of myopia and refractive error in the future.%近视眼为一种常见的屈光不正,是由遗传与环境因素共同作用的结果.近年来近视眼和屈光不正的全基因组关联研究取得了阶段性成果,发现了诸多与近视眼和屈光不正关联的遗传易感位点和区域,近视眼的遗传学研究进入了一个崭新的阶段.本文对目前的主要研究进展进行综述,并展望未来的研究方向.