Accompany with dramatically growth of large-scale biological databases (such as human genome sequence),improvement of life science and development of international clinical trials,science offers great potential for improving health care through precision medicine.As a hot topic recently,precision medicine might launch a revolution of the methodology in medical research.How to achieve precision medicine in clinical ophthalmology by means of biological data mining is a challenge for ophthalmologistscientists.The best approach for advanced individual medicine is to buildup the digital ophthalmology,which includes human eye biobank,national biological databases network,clinical department,basic research lab,and international clinical trial center.The system of digital ophthalmology could explore the methods for ophthalmology research,integrate the source of eye biologic databases,promote international cooperation,and thus eventually supply the opportunity for translational medicine.%随着人类基因组图谱的绘制完成、生命科学的迅猛发展、国际多中心临床试验以及诊断新技术的不断更新,医学研究进入大数据时代,由此衍生的精准医疗成为新的主题词,并引发了医学研究方法论的变革.未来眼科领域,如何利用大数据开展个体化医疗成为新时代的挑战与机遇.以眼科生物样本信息库构建和分析为基础,进行全数字化眼科建设,结合多中心临床试验,通过大数据分析和挖掘,寻找新的干预方案或靶点,是推进新时代个体化医疗的重要手段,也将为拓展临床研究思路、整合基础和临床科研资源配置、开展多中心临床研究和数据分析、推动眼科转化医学发展,提供重要的基础保障.
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