骨髓来源的纤维细胞与甲状腺相关眼病的研究进展

摘要

TAO是一种累及甲状腺和眼眶的自身免疫性疾病,眼部主要病理学改变为眼外肌纤维化和眶内脂肪组织增生.患者的主要临床症状为眶压升高、眼球突出,严重者因视神经受到挤压或角膜溃疡可导致失明.由于缺乏必要的细胞分子学机制依据,所以临床尚无有效的治疗方法.近期研究发现骨髓来源的一种干细胞特征纤维细胞可能参与TAO的发病机制及病理过程.本文就TAO的研究进展及其与骨髓来源纤维细胞的具体关系进行总结和综述.%Thyroid-associated opthalmopathy(TAO) is a common autoimmune syndrome affecting the thyroid and orbit,which can result in the fibrosis of extraoular muscles and hyperplasia of adipose tissue.Advanced TAO patients could even lose vision caused by cornea ulcer and congestion of optic nerve from expansion of the extraocular muscles and orbit fat.Currently,there are no therapies shown to prevent it,because its cellular and molecular mechanisms are not clear.Some studies have recently implicated bone marrow-derived fibroblast-like,called fibrocytes are involved in the pathogenesis of TAO.We reviewed and summarized the research advances of TAO and also the relationship between the fibrocytes and pathogenesis of TAO in the paper.