Objective To observe the efficacy of photodynamic therapy for vitelliform macular dystrophy(VMD) with choroidal neovascularization(CNV).Methods The clinical data of 7 patients (7 eyes) of VMD with CNV who had undergone photodynamic therapy (PDT) were retrospectively analyzed.The patients were 4 males and 3 females,aged from 20 to 54 years.The patients received the examinations of best corrected visual acuity (BCVA),slit-lamp microscopy,fundus photography,fluorescein angiography (FFA),indocyanine green angiography (ICGA),spectral domain OCT(SD-OCT),electrooculogram(EOG)and electroretinogram (ERG)before and after PDT.The BCVA ranged from finger counting to 0.6.Retinal edema and the subretinal fluid were observed.The mean thickness of central retina was (506.00± 30.71)μm.PDT was performed according to the standard treatment.The follow-up period ranged from 2 to 11 months with the mean of 6.3 months.The changes of BCVA,CNV and side effects were observed after treatment.Results BCVA improved in all patients ranging from 0.12 to 1.0.The regression of the CNV and resolution of the subretinal fluid were observed by FFA,ICGA and SD-OCT after PDT.The mean thickness of central retina was reduced to (401.00± 52.22) μm.There was no PDT-associated ocular or systemic side effect.Conclusions PDT is an effective and safe treatment for VMD with CNV.It may improve or stabilize the visual acuity.%目的 观察光动力疗法(PDT)治疗卵黄样黄斑营养不良(VMD)并发脉络膜新生血管(CNV)的临床疗效.方法 回顾性分析行PDT治疗的7例VMD并发CNV患者7只眼的临床资料.患者中男性4例,女性3例.年龄20～54岁.治疗前后行最佳矫正视力(BCVA)、裂隙灯显微镜、眼底彩色照相、荧光素眼底血管造影(FFA)、吲哚青绿血管造影(ICGA)、频域光相干断层扫描(SD-OCT)以及眼电图( EOG)、视网膜电图(ERG)等检查.患眼BCVA数指/眼前～0.6；光感受器内外节(IS/OS)界面下积液,视网膜水肿,平均中央视网膜厚度(506.00±30.71) μm.PDT治疗按照标准常规操作完成.治疗后随访2～11个月,平均随访时间6.3个月.观察BCVA及CNV变化以及与治疗相关的副作用.结果 末次随访时,患眼BCVA 0.12～1.0,均有不同程度提高；FFA及ICGA检查显示,CNV萎缩变小,渗漏减轻；SDOCT检查见神经视网膜水肿减轻或消退,平均中央视网膜厚度下降为(401.00±52.22) μm,IS/OS界面与视网膜色素上皮间光反射暗区消失,黄斑恢复基本正常形态；未见与治疗相关的局部及全身副作用发生.结论 PDT能有效治疗VMD并发的CNV,稳定或提高患者视力.
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