视神经炎患者血清尿酸浓度检测

摘要

目的 观察视神经炎((ON)患者的血清尿酸浓度.方法 临床确诊的39例ON患者(ON组)及年龄、性别与之匹配的69例多发性硬化(MS)患者(MS组)、51例视神经脊髓炎(NMO)患者(NMO组)和53名健康对照者(对照组)纳入研究.ON组患者中,视盘炎25例,球后ON 14例；初发者28例,复发者11例；病程＜1年者28例,病程≥1年者11例.所有受检者均于入院后第2天抽取空腹静脉血,采用尿酸酶-过氧化物酶偶联法检测血清尿酸浓度.对比分析各组受检者之间血清尿酸浓度差异；各组间不同性别者血清尿酸浓度差异；ON组不同病变性质、不同复发情况、不同病程患者间血清尿酸浓度差异.结果 ON组患者血清尿酸浓度较对照组受检者明显降低,差异有统计学意义(t=3.16,P＜0.05).ON组与MS组、ON组与NMO组、MS组与NMO组患者间血清尿酸浓度比较,差异均无统计学意义(t=0.26、0.94、1.36,P＞0.05).ON组、MS组、NMO组女性患者及对照组女性受检者血清尿酸浓度均较男性明显降低,差异均有统计学意义(F=6.27、16.20、21.09、11.96,P＜0.05).ON组男女性患者血清尿酸浓度较对照组男女性受检者明显降低,差异有统计学意义(t=2.13、3.04,P＜0.05).ON组与MS组(t=0.25、0.59)、ON组与NMO组(t=0.33、0.63)、MS组与NMO组(t=0.63、1.41)男女性患者间血清尿酸浓度比较,差异均无统计学意义(P＞0.05).ON组复发者血清尿酸浓度较初发者低(F=2.73),病程≥1年者血清尿酸浓度较病程＜1年者低(F=0.23),球后ON患者血清尿酸浓度较视盘炎患者低(F=0.76),但差异均无统计学意义(P＞0.05).结论 ON患者血清尿酸浓度较正常健康者降低.不同发病情况、不同病程及不同病变部位的ON患者血清尿酸浓度间无明显差异.%Objective To observe serum uric acid (UA) level of patients with optic neuritis (ON).Methods Thirty-nine patients with ON (ON group),53 healthy control subjects (control group),69 patients with multiple sclerosis (MS group) and 51 patients with neuromyelitis optica (NMO group) matched in age and sex were enrolled in the study.In ON group,there were 25 patients with papillitis and 14 patients with retrobulbar type ON.Twenty-eight patients were first time onset while 11 patients were recurrent.The disease duration was less than a year for 28 patients,and over a year for the remainder.Venous blood samples were collected from all individuals in the morning after an overnight fast.UA concentration was measured by the urate oxidase-indirect peroxidase couple assay.Differences of UA concentration were comparatively analyzed among all the groups.UA levels between different genders,different groups,different lesion sites,recurrence and duration of ON were comparatively analyzed.Results Serum UA level in ON group was significantly lower than that in control group (t=3.16,P＜0.05).However,no significant differences were found between ON and MS,ON and NMO,MS and NMO group (t=0.26,0.94,1.36; P＞0.05).Serum UA level was significantly lower in female than in male in all groups (F=6.27,16.20,21.09,11.96; P＜0.05).In male and female patients of ON group,UA levels were significantly lower when compared with same gender in control group(t=2.13,3.04; P＜0.05).However,no differences (P＞0.05) were found between ON and MS of same gender (t=0.25,0.59),ON and NMO of same gender (t=0.33,0.63),MS and NMO of same gender (t=0.63,1.41).Patients with recurrent ON had lower serum UA level than that with first episodes (F=2.73).Patients with duration of over a year had lower serum UA level than that with duration of less than a year (F=0.23).Patients with retrobulbar neuritis also had lower serum UA level than that with papillitis (F=0.76).But the differences were not significant (P＞0.05).Conclusions A reduced serum UA level is found in patients with ON compared with healthy control.But serum UA level is not correlated with recurrence,lesion site or duration of disease.