Objective To evaluate tne dietary effect on patients with dry eye caused by meibomian gland dysfunction (MGD).Methods A prospective study was conducted from January to July 2012,in which 80 patients with MGD related dry eye from the Guangzhou Medical College Attached Guangzhou First People's Hospital were recruited.They were randomly divided into two groups.All the patients received hot compress,eyelid edge cleaning and massage of eyelid,and patients in the experimental group took capsules of perilla seed oil and patients in the contral one tooke capsules of peanut oil,5 pieces a day for 6 months.All the patients were measured with dry eye questionnaire(DEQ) and clinical examination including tear break-up time (BUT),corneal fluorescent staining (FL),Schirmer Ⅰ test (SIT),meibomian gland health,meibum evaluation,cholesterol and blood fat.Results Perilla seed oil provided more benefit to improving the syndrome of dry eye,BUT,FL,meibomian gland form and secretion than peanut oil(P＜0.05).Total cholesterol and triglyceride in the experimetal group descended apparently compared to the contral group(P＜0.05).Conclusions The dietary supplementation of ω-3 unsaturated fattyacid combined with physical therapy plays a significant role in treatment of MGD and clinical symptom and indicators.Combined with local physical and chemical,it will create better effects.%目的 探讨睑板腺功能障碍(MGD)相关性干眼的饮食干预效果.方法 采用前瞻性研究方法,将80例MGD相关性干眼患者随机分成试验组和对照组,每组40例.两组在热敷、眼睑清洁和按摩基础上,分别服用紫苏籽油胶囊和花生油胶囊,5粒/d.干预前及治疗后6个月,行干眼症问卷调查(DEQ)评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL)检查、基础泪液分泌实验(SIT)、睑板腺及其分泌物、血脂等指标检查并进行比较.结果 服用紫苏籽油的试验组较对照组在干眼症状改善、BUT、FL、睑板腺形态和睑板腺分泌物改善方面更具优势(P＜0.05).同时紫苏籽油可降低患者的血总胆固醇和三酰甘油水平(P＜0.05).结论食用富含ω-3不饱和脂肪酸的油脂,同时结合局部护理治疗措施,对改善MGD性干眼症状及体征效果显著.
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