核素标记基质金属蛋白酶抑制剂在动脉粥样硬化斑块显像中的研究进展

摘要

动脉粥样硬化(AS)易损斑块破裂可导致急性心血管病事件.基质金属蛋白酶(MMP)在高危斑块破裂的病理过程中有重要作用,MMP通过降解AS斑块的细胞外基质,使纤维帽变薄,导致斑块破裂,引发心肌缺血或梗死.基质金属蛋白酶抑制剂(MMPI)可特异性结合MMP,抑制MMP活性.核医学分子影像可通过构建靶向MMP的分子探针从分子水平对不稳定性斑块进行检测和评价,研究斑块的生物学特性和监测药物疗效.笔者就核素标记MMPI在AS斑块显像中的研究进展进行综述.%Atherosclerotic vulnerable plaques may cause acute cardiovascular events.Matrix metalloproteinase (MMP) plays an important role in the pathological process of high-risk plaques.It degrades the extracellular matrix of atherosclerotic plaque,thus making the fibrous cap thinner and the plaque more vulnerable,which lead to rupture.MMP inhibitors (MMPI) can specially bind MMP and inhibit its activity.Taking MMP as the target,nuclear medical imaging can identify and evaluate the unstable plaque in molecular level,and can also be used to explore the biological characteristics of plaque,as well as to monitor drug efficiency.This review summarizes the development of nuclide targeted MMPI in atherosclerotic plaque imaging.