乳腺癌及腋淋巴结转移99Tcm-tetrofosmin与99Tcm-MIBI显像的对比研究

摘要

目的比较99Tcm-tetrofosmin和99Tcm-甲氧基异丁基异腈(MIBI)显像诊断乳腺癌和腋淋巴结转移的临床价值。方法对52例乳腺肿瘤患者进行99Tcm-tetrofosmin和99Tcm-MIBI显像。患者均在2周内行外科手术治疗，并做病理检查。结果 26例患者病理检查证实为乳腺癌，其中30例为良性病变。99Tcm-tetrofosmin显像发现乳腺癌21例，其中11例合并腋淋巴结转移；99Tcm-MIBI显像发现乳腺癌19例，其中12例合并腋淋巴结转移。99Tcm-tetrofosmin和99Tcm-MIBI显像对乳腺癌诊断的灵敏度、特异性和准确性分别为80.8％、76.7％、78.6％和73.1％、73.3％、73.2％；诊断腋淋巴结转移的灵敏度、特异性和准确性分别为68.8％、80.0％、76.0％和75.0％、80.0％、76.9％。结论 99Tcm-tetrofosmin显像对乳腺癌的检出优于99Tcm-MIBI显像。%Objective　To evaluate the clinical diagnostic value of 99Tcm-tetrofosmin in the imaging of breast carcinoma and axillary lymph node metastases and to compare with that of 99Tcm-MIBI. Methods　52 females with breast masses were examined by 99Tcm-tetrofosmin scintigraphy and 99Tcm-MIBI scintigraphy.All the results were compared with that from pathologic study. Results　26 patients were found to have a primary malignancy of the breast ,whereas 30 had benign disease. 99Tcm-tetrofosmin breast imaging showed abnormal uptake in 21 of 26 malignancies and in 11 of 16 axillary lymph node metastases.The sensitivity ,specificity, and accuracy values obtained with 99Tcm-tetrofosmin and 99Tcm-MIBI scintigraphy for breast carcinoma were 80.8%, 76.7%, 78.6%,and 73.1%,73.3%,73.2%, respectively. The values obtained with 99Tcm-tetrofosmin and 99Tcm-MIBI scintigraphy for axillary lymph node metastases were 68.8%, 80.0%, 76.0%,and 75.0%,80.0%,76.9%, respectively. Conclusions　Both of the two techniques are effective in the differentiation of malignant breast mass-es from benign ones and in detecting axillary lymph node metastases.However , 99Tcm-tetrofosmin is superior to 99Tcm-MIBI in detecting breast carcinoma.