MIBI

摘要： 近几年我组发现锝药盒产品在夏季会出现萎缩、发黄现象,时有退货发生.我们查阅了相关文献,发现这种现象与冻干品的含水量有关.按照中国药典2015年版二部规定,MDP药盒含水量不得超过0.67mg.而丁基胶塞(以下简称胶塞)的游离水分是冻干药盒中水分的重要来源.

摘要： 目的:探讨SPECT－CT 亲肿瘤融合显像在甲状腺结节诊断中的价值.方法:选取120例甲状腺结节患者作为研究对像,对患者静脉注射99Tcm－甲氧基异丁基异腈(MIBI)后分别行早期和延迟平面现像,在早期平面现像后立即进行SPECT/CT同机断层融合.结果:SPECT－CT 融合显像对甲状腺结节良恶性鉴别的敏感度、特异度和准确度分别为78.43%、75.36% 和76.67%.结论:SPECT－CT 亲肿瘤融合显像用于临床良恶性甲状腺结节的鉴别诊断中的敏感度、特异度和准确度都较高.

摘要： 原发性甲状旁腺功能亢进症(PHPT)是一种常见的、具有潜在破坏性的内分泌系统疾病,手术是其唯一治愈方法.过去近20年来甲状旁腺手术方式发生了改变,常规双侧颈部探测不再是唯一的手术方式.鉴于甲状旁腺核素显像能特异性定位甲状旁腺手术位置、寻找异位甲状旁腺及多腺体疾病,其在手术方式选择上发挥了重要作用.该文是核医学医师、内分泌及内分泌外科医师互相协作的成果,文章强调了在任何PHPT手术前行甲状旁腺显像的重要性,即使是常规双侧颈部探查也应这样执行;讨论了甲状旁腺切除术的优缺点、甲状旁腺核素显像指导手术利弊;讨论了持续或复发的甲状旁腺功能亢进症再次手术界定腺体范围的最优策略;陈述了新型PET示踪剂的潜在应用价值,特别是18F-氟代胆碱.

摘要： 原发性甲状旁腺功能亢进症（PHPT）是一种常见的、具有潜在破坏性的内分泌系统疾病，手术是其唯一治愈方法。过去近20年来甲状旁腺手术方式发生了改变，常规双侧颈部探测不再是唯一的手术方式。鉴于甲状旁腺核素显像能特异性定位甲状旁腺手术位置、寻找异位甲状旁腺及多腺体疾病，其在手术方式选择上发挥了重要作用。该文是核医学医师、内分泌及内分泌外科医师互相协作的成果，文章强调了在任何PHPT手术前行甲状旁腺显像的重要性，即使是常规双侧颈部探查也应这样执行；讨论了甲状旁腺切除术的优缺点、甲状旁腺核素显像指导手术利弊；讨论了持续或复发的甲状旁腺功能亢进症再次手术界定腺体范围的最优策略：陈述了新型PET示踪剂的潜在应用价值，特别是^18F-氟代胆碱。

摘要： 目的:探讨99mTc-MIBI双时相平面显像及早期SPECT/CT断层融合显像对单发及多发性甲状旁腺功能亢进症病灶术前定位的诊断价值.方法:回顾性分析2011年6月至2016年6月间42例(男20例,女22例,年龄53.1±14.8岁)临床诊断为原发或继发性甲状旁腺功能亢进症且获得手术病理结果的患者资料,所有患者均行99mTc-MIBI双时相甲状旁腺平面显像及早期SPECT/CT断层融合显像进行术前定位.以手术病理结果为金标准,分别评价平面显像及早期SPECT/CT断层融合显像对单发及多发性甲状旁腺功能亢进症病灶的诊断效能.结果:42例患者术中共探得甲状旁腺阳性病灶78个,早期SPECT/CT对单发及多发病灶的诊断准确性均显著高于双期平面像,差异有统计学意义(x2=9.195,P＜0.05;x2=9.001,P＜0.05).结论:增加早期SPECT/CT对甲状旁腺功能亢进症术前定位较传统双时相平面显像有较高的增益价值.%Purpose:To evaluate the preoperative localization value of dual-phase 99Tcm-MIBI planar imaging with or without early-phase SPECT/CT in the preoperative localization of parathyroid lesions.Methods:Fortytwo patients (20 males,22 females;mean age 53.1±14.8 years) with primary or secondary hyperparathyroidism who had been undergone parathyroidectomy from June 2011 to June 2016 were analyzed retrospectively.All patients underwent dual-phase 99Tcm-MIBI planar scan and early-phase SPECT/CT scan.Single gland and multi-gland disease of hyperparathyroidism were evaluated by these two imaging groups respectively.The diagnostic efficiencies were calculated according to the pathological results.Results:Seventy-eight abnormal parathyroid lesions were found in 42 patients.The diagnostic accuracy of early-phase SPECT/CT were significantly higher than that of dual-phase planar imaging both for single gland disease and multi-gland disease (x2 =9.195,P＜0.05;x2 =9.001,P＜0.05).Conclusion:The early-phase SPECT/CT imaging has preferable diagnostic value in the preoperative localization of hyperparathyroidism lesions.

摘要： 目的探讨^(99)Tc^m-甲氧基异丁基异腈(MIBI)双时相显像在高甲状旁腺素(PTH)患者中的应用。方法对73例手术确诊的甲状旁腺功能亢进症患者行^(99)Tc^m-MIBI双时相平面显像,必要时行全身显像、CT、SPECT/CT断层融合显像。检测患者术前PTH、血清钙、磷离子浓度以及术后血清钙、磷离子浓度,其中60例患者检测术后1周内PTH水平。结果原发性甲状旁腺功能亢进症(PHPT)患者29例,其中27例病理证实甲状旁腺瘤28处,^(99)Tc^m-MIBI显像阳性病灶27处(诊断敏感性为96.4%,27/28);另2例患者病理证实甲状旁腺增生病灶共3处,^(99)Tc^m-MIBI显像阳性病灶1处(诊断敏感性为33.3%,1/3);^(99)Tc^m-MIBI显像对PHPT总的诊断敏感性为90.3%(28/31)。继发性甲状旁腺功能亢进症(SHPT)患者44例,病理确诊甲状旁腺组织增生154处,^(99)Tc^m-MIBI发现118处浓聚病灶,诊断敏感性为76.6%(118/154)。大部分甲状旁腺瘤放射性浓聚程度高于甲状旁腺增生组织。PHPT以高钙低磷血症为主,SHPT往往血钙升高不明显,但血磷升高明显。患者术后1周内可见PTH不同程度降低。结论^(99)Tc^m-MIBI双时相显像对甲状旁腺瘤的诊断敏感性高于甲状旁腺增生组织;该检查方法能够对功能异常的甲状旁腺组织进行术前定位,有利于提高手术成功率。

摘要： 目的 探讨高血压性左心室肥厚及射血分数保留的心力衰竭（HF－PEF）患者左心室同步性变化，明确收缩失同步对心功能的影响。方法 回顾性分析2011年6月至2014年5月间天津市胸科医院诊治的352例原发性高血压患者资料，其中男160例，女192例，年龄（67.6±7.8）岁。根据心脏超声及G－MPI相位分析技术，利用单因素方差分析、χ2检验比较各组患者的心脏超声参数、相位直方图带宽（PHB）、相位标准差（PSD）和血清BNP值。对于HF－PEF患者，采用偏相关分析探讨BNP与PHB、PSD及其他临床因素的关系。结果 按相应诊断标准，将352例原发性高血压患者分成3组，分别是单纯高血压组（182例）、左心室肥厚组（74例）和HF－PEF组（96例）。与单纯高血压组相比，左心室肥厚组和HF－PEF组均存在：（1）显著心室肥厚，左心室质量指数（LVMI）分别为（121.1±9.8）和（123.2±10.9） g/m2，显著高于单纯高血压组的（94.4±10.1） g/m2（F＝8.66，P〈0.05）；（2）舒张功能减低，舒张早期和舒张晚期二尖瓣血流速率比值（E/A）分别为0.80±0.28和0.67±0.17，显著低于单纯高血压组的1.19±0.23（F＝13.46，P〈0.05）。但3组间LVEF均正常，分别为（58.6±7.3）%、（60.8±10.4）%和（55.1±4.6）%（F＝2.89，P〉0.05）。HF－PEF组存在明显的左心室收缩的失同步，PHB、PSD分别为（88.4±8.6）°、（23.6±1.9）°，血清BNP水平显著高于左心室肥厚组[（228.4±69.7） ng/L和（92.5±13.6） ng/L；q＝8.63，P〈0.05]；血清BNP值与PHB、PSD及LVMI呈正相关（r＝0.277～0.331，均P〈0.05）。结论 高血压所致HF－PEF患者存在明显左心室收缩的失同步，该同步性异常和心力衰竭严重程度有关。

摘要： Objective To investigate the systolic synchrony of the left ventricle in patients with left ventricular hypertrophy (LVH) or with heart failure but preserved ejection fraction (HF-PEF),and to evaluate the impact of systolic dyssynchrony on left ventricular function.Methods During June 2011 to May 2014,a total of 352 patients(160 males,192 females,average age:(67.6±7.8)years) with essential hypertension (EH) were enrolled in this retrospective study.Ultrasonic and G-MP1 were performed for assessment of left ventricular remodeling and systolic synchrony and the results were statistically analyzed by oneway analysis of variance and x2 test.Relationship between BNP and synchronic parameters as well as other clinical factors were analyzed by partial correlation analysis.Results The EH patients were divided into hypertension group (rt =182),LVH group (n =74) and HF-PEF group (n =96).In comparison to hypertension group,significant LVH developed in LVH and HF-PEF groups although the LVEF was still preserved.The LVMI of the 3 groups were (94.4±10.1),(121.1±9.8) and (123.2±10.9) g/m2,respectively(F=8.66,P＜0.05).The LVEF was (58.6±7.3)％,(60.8±10.4)％ and (55.1±4.6)％,respectively(F=2.89,P＞0.05).Diastolic dysfunction was identified in LVH and HF-PEF groups with significantly reduced E/A ratio (1.19±0.23,0.80±0.28,0.67±0.17;F=13.46,P＜0.05).Remarkable left ventricular systolic dyssynchrony with phase histogram bandwidth (PHB) of (88.4±8.6) ° and phase standard deviation (PSD) of (23.6±1.9)° and increased BNP of (228.4±69.7) ng/L were revealed in HF-PEF group.The BNP in HF-PEF group was significantly higher than that in LVH group((92.5±13.6) ng/L;q=8.63,P＜0.05).Positive correlation was found between BNP level and PHB,PSD,LVMI,respectively (r=0.277-0.331,all P＜0.05).Conclusion Left ventricular systolic dyssynchrony is concomitant with HF-PEF patients induced by EH,and this dyssynchrony might be one of the factors leading to diastolic dysfunction.%目的 探讨高血压性左心室肥厚及射血分数保留的心力衰竭(HF-PEF)患者左心室同步性变化,明确收缩失同步对心功能的影响.方法 回顾性分析2011年6月至2014年5月间天津市胸科医院诊治的352例原发性高血压患者资料,其中男160例,女192例,年龄(67.6±7.8)岁.根据心脏超声及G-MPI相位分析技术,利用单因素方差分析、x2检验比较各组患者的心脏超声参数、相位直方图带宽(PHB)、相位标准差(PSD)和血清BNP值.对于HF-PEF患者,采用偏相关分析探讨BNP与PHB、PSD及其他临床因素的关系.结果 按相应诊断标准,将352例原发性高血压患者分成3组,分别是单纯高血压组(182例)、左心室肥厚组(74例)和HF-PEF组(96例).与单纯高血压组相比,左心室肥厚组和HF-PEF组均存在:(1)显著心室肥厚,左心室质量指数(LVMI)分别为(121.1±9.8)和(123.2±10.9) g/m2,显著高于单纯高血压组的(94.4±10.1)g/m2(F=8.66,P＜0.05);(2)舒张功能减低,舒张早期和舒张晚期二尖瓣血流速率比值(E/A)分别为0.80±0.28和0.67±0.17,显著低于单纯高血压组的1.19±0.23(F=13.46,P＜0.05).但3组间LVEF均正常,分别为(58.6±7.3)％、(60.8±10.4)％和(55.1±4.6)％(F=2.89,P＞0.05).HF-PEF组存在明显的左心室收缩的失同步,PHB、PSD分别为(88.4±8.6)°、(23.6±1.9)°,血清BNP水平显著高于左心室肥厚组[(228.4±69.7) ng/L和(92.5±13.6) ng/L;q=8.63,P＜0.05];血清BNP值与PHB、PSD及LVMI呈正相关(r=0.277～0.331,均P＜0.05).结论 高血压所致HF-PEF患者存在明显左心室收缩的失同步,该同步性异常和心力衰竭严重程度有关.

摘要： Objective To investigate the additional diagnostic value of 99Tcm-MIBI SPECT/CT over dual-phase 99Tcm-MIBI scintigraphy in patients with primary hyperparathyroidism (PHPT).Methods Forty patients (14 males,26 females;mean age (55.4±12.4) years) with suspicious PHPT who underwent dual-phase 99Tcm-MIBI scintigraphy and SPECT/CT from April 2008 to November 2012 were retrospectively reviewed.All patients had pathological diagnosis based on surgical resection.There were 160 parathyroid glands in 40 patients.In comparison with the result of pathological diagnosis,the diagnostic efficiency of dual-phase 99Tcm-MIBI scintigraphy and SPECT/CT were evaluated.x2 test was used to compare the diagnostic accuracy of the 2 methods.Results Forty-three abnormal parathyroid lesions were found in 40 patients.Among the 43 lesions,33 were diagnosed as parathyroid adenoma,and 7 were diagnosed as parathyroid hyperplasia by pathology.Using dual-phase 99Tcm-MIBI scintigraphy and SPECT/CT for the diagnosis of PHPT,the sensitivity,specificity,accuracy,negative predictive value,positive predictive value were 74.4％(32/43)vs 93.0％(40/43),97.4％(114/117) vs 100％(117/117),91.2％(146/160) vs 98.1％(157/160),91.2％(114/125) vs 97.5％(117/120),91.4％(32/35) vs 100％(40/40),respectively.The diagnostic accuracies of the above two imaging modalities were significantly different (x2 =1.125,P＜0.01).Conclusion Compared with dual-phase 99Tcm-MIBI scintigraphy imaging,the diagnostic accuracy of SPECT/CT on PHPT is significantly improved.%目的 探讨99Tcm-MIBI SPECT/CT显像对原发性甲状旁腺功能亢进症(PHPT)的诊断价值.方法 回顾性分析2008年4月至2012年11月40例[男14例,女26例,年龄(55.4±12.4)岁)]临床疑似PHPT且获得手术病理结果的患者资料.所有患者均行99 Tcm-MIBI双时相平面显像及SPECT/CT显像.以术中所见病理诊断及术后PTH水平为标准,分别计算99Tcm-MIBI双时相平面显像及SPECT/CT显像对PHPT的诊断效能.每例患者按4个甲状旁腺计,40例共160个.采用x2检验比较2种检查方法诊断的准确性.结果 共计切除40例患者的甲状旁腺病灶43个,病理诊断甲状旁腺腺瘤33例,甲状旁腺增生7例.99Tcm-MIBI双时相平面显像和SPECT/CT显像对PHPT的诊断灵敏度、特异性、阴性预测值、阳性预测值和准确性分别为74.4％(32/43)和93.0％ (40/43),97.4％(114/117)和100％(117/117),91.2％(114/125)和97.5％(117/120),91.4％ (32/35)和100％(40/40),91.2％(146/160)和98.1％(157/160).2种检查方法准确性间的差异有统计学意义(x2=1.125,P＜0.01).结论 SPECT/CT显像诊断PHPT较99Tcm-MIBI双时相平面显像具有更高的准确性.

摘要： 目的 探讨肥厚型心肌病(HCM)合并陈旧心肌梗死核素MPI的特点,比较合并与未合并冠心病的HCM患者MPI差异.方法 回顾性分析2006年10月至2014年10月间在阜外医院住院的34例HCM合并心肌梗死的患者[其中男26例,女8例,年龄40～80(57±11)岁]99Tcm-MIBISPECT静息MPI资料.按冠状动脉造影或螺旋CT结果确定患者是否合并冠心病(1支或1支以上血管狭窄≥50％为阳性),将患者分为HCM合并冠心病组(组1)和不合并冠心病组(组2).采用17节段半定量评分法计算左心室心肌各节段评分,采用两独立样本t检验对2组患者的评分进行比较.结果 34例HCM中,MPI示节段性放射性浓聚24例,有心肌梗死表现(节段性放射性稀疏至缺损)28例.半定量评分结果:组1(20例)与组2(14例)前壁近心尖段[(0.60±1.27)与(1.57±1.45),t=2.067]、前壁中段(0.20±0.52与0.86±1.29,t=2.056)、侧壁近心尖段(0.30±0.98与1.21±1.48,t=2.175),评分差异有统计学意义(均P＜0.05),其余14个节段评分差异无统计学意义(t值:-1.849～2.175,均P＞0.05).结论 HCM患者即使不存在有意义的冠状动脉狭窄,当发生心肌梗死时,其心肌受损的范围、程度也均较严重.%Objective To investigate 99Tcm-MIBI SPECT MPI characteristics in patients with hypertrophic cardiomyopathy (HCM) complicated with old myocardial infarction (OMI),and to compare the differences of MPI between HCM patients with or without coronary artery disease (CAD).Methods From October 2006 to October 2014,34 patients with HCM complicated with OMI (26 males and 8 females;mean age:(57±11) years) underwent rest 99Tcm-MIBI SPECT MPI in Fu Wai Hospital.The MPI data were retrospectively analyzed.Patients with one or more coronary vessels stenosis ≥ 50％ found by coronary angiography or spiral CT,were considered CAD-positive.Patients were divided into two groups:group 1 including 20 HCM patients with CAD,group 2 including 14 HCM patients without CAD.Semi-quantitative perfusion evaluation was performed in 17 segments,and the scores were compared between two groups using twosample t test.Results In 34 HCM patients,there were 24 patients showed segmental increased uptake on MPI,and 28 patients showed decreased uptake or defect on MPI,which demonstrating the existence of myocardial infarction (MI).Only apical anterior (0.60±1.27 vs 1.57±1.45,t=2.067),mid anterior (0.20±0.52vs 0.86± 1.29,t =2.056) and apical lateral segments (0.30±0.98 vs 1.21 ± 1.48,t =2.175) exhibited significant differences between group 1 and group 2(all P＜0.05).Other 14 segments exhibited no significant differences(t:1.849-2.175,all P＞0.05).Conclusion When MI occurred,a serious myocardial damage both in range and extent could be found in HCM patients even without significant coronary artery stenosis.

摘要： 目的：探讨甲状旁腺功能亢进症(HPT)患者行99Tcm-MIBI与99TcmO4—联合显像对甲状旁腺功能亢进病变的定位诊断价值。rn 方法：原发性HPT 患者36 例，对照组10 例为甲状腺疾病患者。99Tcm-MIBI 注射后15min行早期相甲状旁腺显像，2h 后行延迟显像。相隔24h 后加做99TcmO4—甲状腺显像，对两种图像进行对比分析、视觉相减及图像判断。rn 结果：36 例甲旁亢患者99Tcm-MIBI/ 99TcmO4—联合显像在甲旁腺部位或其邻近部位出现局限性核素明显增浓的阳性结果34 例，假阴性结果2例，阳性率为94.44%；36例甲旁亢患者单行99Tcm-MIBI 显像检出阳性结果12 例，假阴性结果4 例，可疑阳性结果20 例，阳性率88.89%(其中55.56%为可疑阳性)。10例对照组单行99Tcm-MIBI显像出现假阳性结果3例，可疑假阳性结果1例，加做99TcmO4—显像后，对照组无假阳性结果。rn 结论： 99Tcm-MIBI/ 99TcmO4 —联合显像可提高HPT 病变诊断的阳性率，减假阳性结果的发生，对单行99Tcm-MIBI 显像出现可疑阳性结果者，联合显像有利于结果的准确判断，对甲状旁腺腺瘤的诊断与定位诊断有重要价值。

摘要： 目的：探讨甲状旁腺功能亢进症(HPT)患者行99Tcm-MIBI与99TcmO4—联合显像对甲状旁腺功能亢进病变的定位诊断价值。rn 方法：原发性HPT 患者36 例，对照组10 例为甲状腺疾病患者。99Tcm-MIBI 注射后15min行早期相甲状旁腺显像，2h 后行延迟显像。相隔24h 后加做99TcmO4—甲状腺显像，对两种图像进行对比分析、视觉相减及图像判断。rn 结果：36 例甲旁亢患者99Tcm-MIBI/ 99TcmO4—联合显像在甲旁腺部位或其邻近部位出现局限性核素明显增浓的阳性结果34 例，假阴性结果2例，阳性率为94.44%；36例甲旁亢患者单行99Tcm-MIBI 显像检出阳性结果12 例，假阴性结果4 例，可疑阳性结果20 例，阳性率88.89%(其中55.56%为可疑阳性)。10例对照组单行99Tcm-MIBI显像出现假阳性结果3例，可疑假阳性结果1例，加做99TcmO4—显像后，对照组无假阳性结果。rn 结论： 99Tcm-MIBI/ 99TcmO4 —联合显像可提高HPT 病变诊断的阳性率，减假阳性结果的发生，对单行99Tcm-MIBI 显像出现可疑阳性结果者，联合显像有利于结果的准确判断，对甲状旁腺腺瘤的诊断与定位诊断有重要价值。

摘要： 目的：探讨甲状旁腺功能亢进症(HPT)患者行99Tcm-MIBI与99TcmO4—联合显像对甲状旁腺功能亢进病变的定位诊断价值。rn 方法：原发性HPT 患者36 例，对照组10 例为甲状腺疾病患者。99Tcm-MIBI 注射后15min行早期相甲状旁腺显像，2h 后行延迟显像。相隔24h 后加做99TcmO4—甲状腺显像，对两种图像进行对比分析、视觉相减及图像判断。rn 结果：36 例甲旁亢患者99Tcm-MIBI/ 99TcmO4—联合显像在甲旁腺部位或其邻近部位出现局限性核素明显增浓的阳性结果34 例，假阴性结果2例，阳性率为94.44%；36例甲旁亢患者单行99Tcm-MIBI 显像检出阳性结果12 例，假阴性结果4 例，可疑阳性结果20 例，阳性率88.89%(其中55.56%为可疑阳性)。10例对照组单行99Tcm-MIBI显像出现假阳性结果3例，可疑假阳性结果1例，加做99TcmO4—显像后，对照组无假阳性结果。rn 结论： 99Tcm-MIBI/ 99TcmO4 —联合显像可提高HPT 病变诊断的阳性率，减假阳性结果的发生，对单行99Tcm-MIBI 显像出现可疑阳性结果者，联合显像有利于结果的准确判断，对甲状旁腺腺瘤的诊断与定位诊断有重要价值。

摘要： 目的：探讨甲状旁腺功能亢进症(HPT)患者行99Tcm-MIBI与99TcmO4—联合显像对甲状旁腺功能亢进病变的定位诊断价值。rn 方法：原发性HPT 患者36 例，对照组10 例为甲状腺疾病患者。99Tcm-MIBI 注射后15min行早期相甲状旁腺显像，2h 后行延迟显像。相隔24h 后加做99TcmO4—甲状腺显像，对两种图像进行对比分析、视觉相减及图像判断。rn 结果：36 例甲旁亢患者99Tcm-MIBI/ 99TcmO4—联合显像在甲旁腺部位或其邻近部位出现局限性核素明显增浓的阳性结果34 例，假阴性结果2例，阳性率为94.44%；36例甲旁亢患者单行99Tcm-MIBI 显像检出阳性结果12 例，假阴性结果4 例，可疑阳性结果20 例，阳性率88.89%(其中55.56%为可疑阳性)。10例对照组单行99Tcm-MIBI显像出现假阳性结果3例，可疑假阳性结果1例，加做99TcmO4—显像后，对照组无假阳性结果。rn 结论： 99Tcm-MIBI/ 99TcmO4 —联合显像可提高HPT 病变诊断的阳性率，减假阳性结果的发生，对单行99Tcm-MIBI 显像出现可疑阳性结果者，联合显像有利于结果的准确判断，对甲状旁腺腺瘤的诊断与定位诊断有重要价值。

摘要： 目的：探讨甲状旁腺功能亢进症(HPT)患者行99Tcm-MIBI与99TcmO4—联合显像对甲状旁腺功能亢进病变的定位诊断价值。rn 方法：原发性HPT 患者36 例，对照组10 例为甲状腺疾病患者。99Tcm-MIBI 注射后15min行早期相甲状旁腺显像，2h 后行延迟显像。相隔24h 后加做99TcmO4—甲状腺显像，对两种图像进行对比分析、视觉相减及图像判断。rn 结果：36 例甲旁亢患者99Tcm-MIBI/ 99TcmO4—联合显像在甲旁腺部位或其邻近部位出现局限性核素明显增浓的阳性结果34 例，假阴性结果2例，阳性率为94.44%；36例甲旁亢患者单行99Tcm-MIBI 显像检出阳性结果12 例，假阴性结果4 例，可疑阳性结果20 例，阳性率88.89%(其中55.56%为可疑阳性)。10例对照组单行99Tcm-MIBI显像出现假阳性结果3例，可疑假阳性结果1例，加做99TcmO4—显像后，对照组无假阳性结果。rn 结论： 99Tcm-MIBI/ 99TcmO4 —联合显像可提高HPT 病变诊断的阳性率，减假阳性结果的发生，对单行99Tcm-MIBI 显像出现可疑阳性结果者，联合显像有利于结果的准确判断，对甲状旁腺腺瘤的诊断与定位诊断有重要价值。

摘要： 本发明属于甲状旁腺功能疾病诊断技术领域，具体涉及一种甲状旁腺MIBI图像分析系统、计算机设备及存储介质。本发明的计算机设备用于实现如下甲状旁腺MIBI图像分析的步骤：步骤1，对甲状旁腺的MIBI图像进行预处理后输入深度学习模型；步骤2，深度学习模型进行计算后，输出所述甲状旁腺的MIBI图像的分类结果；其中，所述深度学习模型通过如下方法构建得到：对四种卷积神经网络模型分别建模并融合，构建最终的深度学习模型。本发明还提供了实现上述分析步骤的系统，包括子模型训练模块、子模型融合模块、测试模块、使用模块、降噪模块和增强模块。本发明通过对多种子模型的融合，具有扬长避短的效果，提高了准确性和鲁棒性，具有很好的应用前景。