无机纳米晶体量子点光学成像应用进展

摘要

光学成像是分子成像技术的重要组成部分,主要包括荧光成像、生物发光成像及扩散光学成像.无机纳米晶体量子点(QDs)因具有独特光学性质(如激发光谱宽且连续、发射光谱窄且对称、荧光强度高、抗光漂白能力强等)而成为光学成像的热点研究领域.该文综述了QDs的光学性质、在光学成像中的体内外应用、局限性及目前存在的问题.%Optical imaging is one of the molecular imaging modalities,and it consists of three imaging methods (fluorescence,bioluminescence and diffusion imaging).For fluorescence imaging,quantum dots (QDs) are inorganic semiconductor nanocrystals with a diameter from 2 to 100 nm.Compared with organic fluorescent dye,QDs have several unique optical properties,such as wide and continuous excitation spectra,narrow and symmetrical emission spectrum,strong fluorescence intensity and high resistance to photobleaching.This article reviews the optical properties of QDs and their development in the field of molecular imaging from in vitro and in vivo applications,as well as the limitations and problems.