Objective; To investigate the situation and rationality of the off-label indications in the outpatient and emergency departments of our hospital, and to promote clinically rational drug use. Methods; A total of 30 647 prescriptions of the outpatient and emergency dep- nents of our hospital from 2010 -06 -21 to 2010 -06 -27 were collected. According to the indications of drug instructions, the prescriptions were screened to comprehensively understand the situation of the off-label indications in our hospital. At the same time, the literature was searched to analyze the rationality of these uses. Results; In this investigation, the off-label indications mainly existed in 16 drugs. The off-label indications of reproductive-related medications were the main, involving 8 types of drugs. Conclusion; The situation of the off-label indications needs attention of both doctors and pharmacists. We should put patients' drug safety in the first place, and avoid the off-label use.%目的:了解我院门急诊处方超适应证使用的情况及其合理性,促进临床合理用药.方法:收集我院2010年6月21-27日的门急诊处方,共计30647张.根据药品说明书的适应证对纳入处方进行筛查,全面了解本院药物说明书适应证外使用情况,同时通过检索文献对超适应证用药的合理性进行分析和讨论.结果:本次调查中主要发现了16个药品有典型的适应证外用药,其中生殖相关用药适应证外用药情况最多,主要涉及8种药物.结论:超适应证用药需要医生和药师共同关注,我们要把患者用药安全放在第一位,规范超说明书用药.
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