Objective To explore the related factors of cerebral palsy in twin or multiple pregnancies ,and the effect of early intervention on prognosis .Methods One hundred and fifty nine cases of twin or multiple pregnancy from 86 families in the perinatal period were investigated by retrospective investigation and analysis method , and as-sessed them by Gesell scale at the same time, the results were comprehensively analyzed .Results There were 106 cases of cerebral palsy in 159 cases twin or multiple pregnancies , the cerebral palsy rate was 66.7%(106/159). There were 94 cases of cerebral palsy among 143 babies of twin or multiple pregnancies , the cerebral palsy rate was 65.7%(94/143).After the rehabilitation treatment, the cerebral palsy rate was 14.5%(23/159), There were many high risk factors of cerebral palsy , which in turn was premature birth, low birth weight, hyperbilirubinemia, hypoxic ischemic encephalopathy, asphyxia, neonatal pneumonia, hypoglycemia, gestational diabetes, in-vitro fertilization and cesarean section.Conclusion Twin or multiple pregnancies are prong to premature birth; there were positive correlation between infantile cerebral palsy and their high risk factors .But early intervention could significantly re-duce the incidence of cerebral palsy , and the smaller age of rehabilitation therapy , the better results, and the optimal treatment time window was before 6 months age.%目的探讨双（多）胎儿发生脑瘫的相关因素及早期干预对预后的影响。方法采用回顾性调查分析的方法，对86个家庭的159例双胎或多胎患儿进行围产期调查，同时给予Gesell测评，并对结果进行综合分析。结果159例多（双）胎儿中诊断脑瘫106例，脑瘫发生率为66.7％，其中婴儿脑瘫94例（65.7％），康复治疗后治愈83例，最终脑瘫发生率为14.5％（23/159）。脑瘫的高危因素依次为早产、低出生体重、高胆红素血症、缺氧缺血性脑病、窒息、新生儿肺炎、低血糖、妊娠糖尿病、试管婴儿和剖宫产等。结论多（双）胎儿易发生早产，婴儿期脑瘫发生与伴有的高危因素呈正相关，但早期干预可显著降低脑瘫发生率，康复治疗的年龄越小，效果越好，治疗的最佳时间窗为6个月龄以前。
展开▼
