帕金森病轻度认知功能障碍的筛查及相关因素分析

摘要

Objective To explore the screening methods and the related factors of mild cognitive impairment (MCI) in patients with Parkinson′s disease(PD).Methods Montreal Cognitive Assessment(MoCA)(Beijing Ver-sion) was used as cognition assessment implement.Thirty-eight PD patients with mild cognitive impairment were cho-sen as research group( MCI group) , and 30 PD patients with normal cognitive function was chosen as control group. In all subjects the creatinine( CREA) , Triglyceride( TG) , cholesterol( CHOL) , high density lipoproteins( HDL-C) , alanine transarninase(ALT), glutamic-oxalacetic transaminase(AST) was measured.Results (1)Between MCI group and control group:there were significant differences in the duration of PD,BMI,abdominal perimeter,LDL-C, HDL-C, CHOL(P<0.05) and no significant differences in TG,ALT,AST and CREA.(2)There was negative corre-lation between the MoCA scores and the LDL-C in MCI group(r=-0.255,P<0.05).Conclusion The risk factors such as longer duration, obesity and high level of blood fat contribute to the development of cognitive impairment and may even aggravate it.So reduction of body weight and control of blood fat may help to improve the cognitive func-tion.%目的：探讨帕金森病轻度认知功能障碍（ MCI）的筛查方法以及相关因素。方法利用蒙特利尔认知评估（ MoCA）北京版量表作为评估患者认知功能的工具，选择帕金森伴有轻度认知功能障碍的38例患者作为研究对象（ MCI组），而帕金森病无认知功能障碍的患者30例作为对照组。入选的患者均进行血中总胆固醇（ CHOL）、甘油三酯（ TG ）、低密度脂蛋白胆固醇（ LDL-C ）、高密度脂蛋白胆固醇（ HDL-C ）、肌酐（CREA）、谷丙转氨酶（ALT）、谷草转氨酶（AST）等检查。结果（1）MCI组与对照组相比，帕金森病病程、BMI、腹围差异具有统计学意义（ P＜0.05）；血中CHOL、LDL-C、HDL-C指标差异具有统计学意义（ P＜0.05）；血中TG、ALT、AST、CREA指标差异无统计学意义。（2）MCI组MoCA评分与LDL-C呈负相关（r＝-0.255，P＜0.05）。结论帕金森病病程长、血脂水平高以及肥胖等因素与患者的认知功能相关，并有可能会加重患者认知功能的损害。提示控制血脂，减轻体重，有助于改善患者认知功能。