肺炎链球菌尿抗原测定方法用于成人社区获得性肺炎快速诊断的研究

摘要

Objective To evaluate the clinical significance of urinary antigen detection for rapid diagnosis in patients with community-acquired pneumonia and to understand the practical value in basic level hospitals.Methods One hundred and two adults with community-acquired pneumonia were enrolled in this study from March 2014 to April 2015 in three hospitals.Their serum and urine were collected and the pneumococcal antigens in the urine were detec-ted using the Binax immmunochromatographic test( ICT) .Bacteria were cultured from sputum.Results Among 102 cases with community-acquired pneumonia, the urine ICT was positive in 15.69%( 16/102 ) .Sputum culture was positive in 2.99%(2/67).The total positive rate of pathogens was 19.61%(20/102).Conclusion Urinary antigen detection provides a credible rapid diagnostic test for pneumococcal pneumonia.It is suitable for applying in basic level hospitals.%目的：了解肺炎链球菌尿抗原测定方法用于快速诊断成人社区获得性肺炎的临床意义及在基层医院推广价值。方法收集2014－03～2015－04吉林省人民医院、前郭县人民医院及长春市二道区医院成人社区获得性肺炎住院患者102例尿标本，用免疫层析法测定肺炎链球菌尿抗原，同时对67例患者进行痰培养和23例患者血培养与鉴定。结果102例患者尿肺炎链球菌抗原阳性率为15．69％（16／102），肺炎链球菌痰培养阳性率为2．99％（2／67），血培养表皮葡萄球菌阳性率为4．35％（1／23），病原体总检出率为19．61％（20／102）。结论尿抗原测定方法明显提高肺炎链球菌所致成人社区获得性肺炎的检出率，对肺炎链球菌成人社区获得性肺炎的快速诊断具有良好的应用前景，尤其在基层医院具有推广价值。